Minimal residual disease status determined by multiparametric flow cytometry pretransplantation predicts the outcome of patients with ALL receiving unmanipulated haploidentical allografts

• Published in: American journal of hematology Vol. 94; no. 5; pp. 512 - 521
• Main Authors: Zhao, Xiao‐Su, Liu, Yan‐Rong, Xu, Lan‐Ping, Wang, Yu, Zhang, Xiao‐Hui, Chen, Huan, Chen, Yu‐Hong, Han, Wei, Sun, Yu‐Qian, Yan, Chen‐Hua, Mo, Xiao‐Dong, Wang, Ya‐Zhe, Fan, Qiao‐Zhen, Wang, Xin‐Yu, Liu, Kai‐Yan, Huang, Xiao‐Jun, Chang, Ying‐Jun
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2019
• Subjects: Acute lymphoblastic leukemia; Adolescent; Adult; Allografts; Child; Child, Preschool; Disease-Free Survival; Female; Flow Cytometry; Hematology; Humans; Leukemia; Lymphatic leukemia; Male; Middle Aged; Minimal residual disease; Multivariate analysis; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy; Preoperative Care; Retrospective Studies; Stem Cell Transplantation; Survival Rate; Time Factors
• ISSN: 0361-8609; 1096-8652; 1096-8652
• DOI: 10.1002/ajh.25417

This study evaluated the effects of pretransplantation minimal residual disease (pre‐MRD) on outcomes of patients with acute lymphoblastic leukemia (ALL) who underwent unmanipulated haploidentical stem cell transplantation (haplo‐SCT). A retrospective study including 543 patients with ALL was perfor...