Translocation of CD45RA in neutrophils

• Published in: Journal of leukocyte biology Vol. 49; no. 4; pp. 317 - 328
• Main Authors: Caldwell, Charles W., Patterson, William P., Yesus, Yohannes W.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Society for Leukocyte Biology 01.04.1991; Federation of American Societies for Experimental Biology
• Subjects: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antigens, Differentiation - biosynthesis; Biological and medical sciences; Calcimycin - pharmacology; Calcium - pharmacology; Calcium Channel Blockers - pharmacology; Calmodulin - antagonists & inhibitors; Calmodulin - physiology; Cell Membrane - metabolism; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene Expression Regulation; Histocompatibility Antigens - biosynthesis; Humans; Immunobiology; Isoantigens; Isoquinolines - pharmacology; Leukocyte Common Antigens; Myeloid cells: ontogeny, maturation, markers, receptors; Neutrophils - metabolism; Piperazines - pharmacology; Polynuclears; Protein Kinase Inhibitors; Protein Kinases - physiology; protein tyrosine phosphatase; Sulfonamides - pharmacology; T200 antigen; Tetradecanoylphorbol Acetate - pharmacology; Time Factors; tyrosine phosphatase; Up-Regulation - drug effects; Human; Translocation; Flow cytometry; Calcium; Induction; Neutrophile; Granulocyte; Stimulation; Ionophore; Cell surface; Cytoplasm

The CD45 family of high‐Mr glycoprotein antigens is expressed in some molecular form on all lymphohematopoietic cells. Different cell types express various isoforms in a precisely programmed fashion. In addition to cell surface CD45 antigens, we recently demonstrated a cytoplasmic granule‐associated...