Pan‐cancer analysis of iron metabolic landscape across the Cancer Genome Atlas

• Published in: Journal of cellular physiology Vol. 235; no. 2; pp. 1013 - 1024
• Main Authors: Zhang, Su, Chang, Wei, Wu, Hao, Wang, Yu‐Han, Gong, Yu‐Wen, Zhao, You‐Li, Liu, Shan‐Hui, Wang, Han‐Zhang, Svatek, Robert S., Rodriguez, Ronald, Wang, Zhi‐Ping
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.02.2020
• Subjects: Cancer; Cell proliferation; Clear cell-type renal cell carcinoma; Deferoxamine; Deoxyribonucleic acid; DNA; DNA methylation; Epigenetics; Ferroptosis; Gene expression; Genes; Genomes; Iron; iron metabolism; Metal ions; pan‐cancer analysis; Proteomics; survival; Therapeutic applications; Tumor cells; iron metabolism; DNA methylation; ferroptosis; survival; pan-cancer analysis

Iron is an essential metal ion in the human body and usually dysregulated in cancers. However, a comprehensive overview of the iron‐related genes and their clinical relevance in cancer is lacking. In this study, we utilized the expression profiling, proteomics, and epigenetics from the Cancer Genome...