An association of neovascular age‐related macular degeneration with polymorphisms of CFH, ARMS2, HTRA1 and C3 genes in Czech population

• Published in: Acta ophthalmologica (Oxford, England) Vol. 98; no. 6; pp. e691 - e699
• Main Authors: Matušková, Veronika, Zeman, Tomáš, Ewerlingová, Laura, Hlinomazová, Zuzana, Souček, Jan, Vlková, Eva, Goswami, Nandu, Balcar, Vladimir J., Šerý, Omar
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2020
• Subjects: Age; Aged; Aged, 80 and over; C3 gene; Case-Control Studies; Complement C3 - genetics; Complement component C3; Complement factor H; Complement Factor H - genetics; Czech Republic; Female; gene; Gene polymorphism; Genes; Genotype & phenotype; High-Temperature Requirement A Serine Peptidase 1 - genetics; Humans; inflammation; Macular degeneration; Macular Degeneration - genetics; Male; obesity; Obesity, Abdominal - complications; Polymorphism; Polymorphism, Single Nucleotide; Population; Proteins - genetics; retina; risk; Risk Factors; Serine; Serine proteinase; Sex differences; Sex Factors; Statistical analysis; Surgery; Temperature requirements; Czech Republic; polymorphism; risk; gene; inflammation; retina; obesity

Purpose We investigated associations between neovascular age‐related macular degeneration (AMD) and rs10490924 polymorphism of ARMS2 gene (age‐related maculopathy susceptibility 2), rs1061170 polymorphism of gene for complement factor H (CFH), rs2230199 polymorphism of gene for complement component...