No evidence for a direct effect of von Willebrand factor's ABH blood group antigens on von Willebrand factor clearance

• Published in: Journal of thrombosis and haemostasis Vol. 13; no. 4; pp. 592 - 600
• Main Authors: Groeneveld, D. J., Bekkum, T., Cheung, K. L., Dirven, R. J., Castaman, G., Reitsma, P. H., Vlijmen, B., Eikenboom, J.
• Format: Journal Article
• Language: English
• Published: England Elsevier Limited 01.04.2015
• Subjects: ABO Blood-Group System - blood; ABO blood‐group system; Animals; Biomarkers - blood; blood group antigens; Drug Combinations; Factor VIII - administration & dosage; Female; Humans; Infusions, Intravenous; Male; Mice, Inbred C57BL; Mice, Knockout; Protein Binding; Time Factors; type 3 VWD; von Willebrand disease; von Willebrand Disease, Type 3 - blood; von Willebrand Disease, Type 3 - diagnosis; von Willebrand Disease, Type 3 - drug therapy; von Willebrand factor; von Willebrand Factor - administration & dosage; von Willebrand Factor - genetics; von Willebrand Factor - metabolism; von Willebrand disease; ABO blood-group system; blood group antigens; von Willebrand factor; type 3 VWD

Summary Background One of the major determinants of von Willebrand factor (VWF) plasma levels is ABO blood group status, and individuals with blood group O have ~ 25% lower plasma levels. The exact mechanism behind this relationship remains unknown, although effects on clearance have been postulated...