Innervation of an engineered muscle graft for reconstruction of muscle defects

• Published in: American journal of transplantation Vol. 19; no. 1; pp. 37 - 47
• Main Authors: Kaufman, Tal, Kaplan, Ben, Perry, Luba, Shandalov, Yulia, Landau, Shira, Srugo, Itay, Ad‐El, Dean, Levenberg, Shulamit
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2019
• Subjects: Abdominal wall; animal models; Animals; Autografts; Axons - physiology; basic (laboratory) research/science; bioengineering; Cell Line; cellular transplantation (non‐islet); Electromyography; Femur; Fibroblasts - cytology; Green Fluorescent Proteins - metabolism; Human Umbilical Vein Endothelial Cells; Humans; Innervation; Male; Mice; Mice, Nude; murine; Muscle, Skeletal - innervation; Muscle, Skeletal - transplantation; Muscles; Muscular Diseases - surgery; Muscular system; Nerve conduction; Nerve Regeneration; Neuromuscular junctions; Polyesters - chemistry; Polylactic Acid-Polyglycolic Acid Copolymer - chemistry; regenerative medicine; Skin & tissue grafts; Tissue engineering; Tissue Engineering - methods; Tissue Scaffolds; murine; animal models; cellular transplantation (non-islet); regenerative medicine; basic (laboratory) research/science; bioengineering

Autologous muscle flaps are commonly used to reconstruct defects that involve muscle impairment. To maintain viability and functionality of these flaps, they must be properly vascularized and innervated. Tissue‐engineered muscles could potentially replace autologous muscle tissue, but still require...