Deep sequencing of prostaglandin‐endoperoxide synthase (PTGE) genes reveals genetic susceptibility for cross‐reactive hypersensitivity to NSAID

• Published in: British journal of pharmacology Vol. 178; no. 5; pp. 1218 - 1233
• Main Authors: García‐Martín, Elena, García‐Menaya, Jesús M., Esguevillas, Gara, Cornejo‐García, José A., Doña, Inmaculada, Jurado‐Escobar, Raquel, Torres, María J., Blanca‐López, Natalia, Canto, Gabriela, Blanca, Miguel, Laguna, José J., Bartra, Joan, Rosado, Ana, Fernández, Javier, Cordobés, Concepción, Agúndez, José A.G.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.03.2021
• Subjects: Copy number; cycloxygenase; Enzymatic activity; Exons; Hypersensitivity; Inflammation; Nonsteroidal anti-inflammatory drugs; NSAID; PTGS1; PTGS2; Risk factors; Sequence analysis; hypersensitivity; cycloxygenase; PTGS2; NSAID; PTGS1

Background and Purpose Cross‐reactive hypersensitivity to nonsteroidal anti‐inflammatory drugs (NSAIDs) is a relatively common adverse drug event caused by two or more chemically unrelated drugs and that is attributed to inhibition of the COX activity, particularly COX‐1. Several studies investigate...