Accelerated vascularization of a novel collagen hydrogel dermal template

• Published in: Journal of tissue engineering and regenerative medicine Vol. 16; no. 12; pp. 1173 - 1183
• Main Authors: Weisel, Adam, Cohen, Rachael, Spector, Jason A., Sapir‐Lekhovitser, Yulia
• Format: Journal Article
• Language: English
• Published: England Hindawi Limited 01.12.2022
• Subjects: Animals; Collagen; Collagen - pharmacology; Computer architecture; Dermis; dermis regeneration; full‐thickness skin loss; hydrogel composite scaffold; Hydrogels; Hydrogels - pharmacology; Immobilization; Immune response; Quality of Life; Rats; Regeneration (physiology); Regenerative medicine; Scaffolds; Skin; Skin grafts; Skin Transplantation - methods; Thickness; Tissue engineering; Tissues; Vascularization; Wound Healing; full-thickness skin loss; dermis regeneration; wound healing; hydrogel composite scaffold

Full thickness skin loss is a debilitating problem, most commonly reconstructed using split thickness skin grafts (STSG), which do not reconstitute normal skin thickness and often result in suboptimal functional and esthetic outcomes that diminish a patient's quality of life. To address the min...