Thalassemia Bone Disease: A 19‐Year Longitudinal Analysis

• Published in: Journal of bone and mineral research Vol. 29; no. 11; pp. 2468 - 2473
• Main Authors: Wong, Phillip, Fuller, Peter J, Gillespie, Matthew T, Kartsogiannis, Vicky, Kerr, Peter G, Doery, James CG, Paul, Eldho, Bowden, Donald K, Strauss, Boyd J, Milat, Frances
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.11.2014
• Subjects: Adult; Blood Transfusion; BONE DENSITY; BONE DISEASE; Child; Female; Follow-Up Studies; Humans; Iron Chelating Agents - administration & dosage; Iron Overload - etiology; Iron Overload - metabolism; Iron Overload - pathology; Iron Overload - therapy; Longitudinal Studies; Male; OSTEOPOROSIS; Osteoporosis - etiology; Osteoporosis - metabolism; Osteoporosis - pathology; Osteoporosis - therapy; Sex Factors; THALASSEMIA; Thalassemia - complications; Thalassemia - etiology; Thalassemia - metabolism; Thalassemia - pathology; Thalassemia - therapy; BONE DENSITY; BONE DISEASE; OSTEOPOROSIS; THALASSEMIA

ABSTRACT Thalassemia is an inherited disorder of alpha or beta globin chain synthesis leading to ineffective erythropoiesis requiring chronic transfusion therapy in its most severe form. This leads to iron overload, marrow expansion, and hormonal complications, which are implicated in bone deformity...