Microsomal prostaglandin E synthase‐1 is involved in the metabolic and cardiovascular alterations associated with obesity

• Published in: British journal of pharmacology Vol. 179; no. 11; pp. 2733 - 2753
• Main Authors: Ballesteros‐Martínez, Constanza, Rodrigues‐Díez, Raquel, Beltrán, Luis M., Moreno‐Carriles, Rosa, Martínez‐Martínez, Ernesto, González‐Amor, María, Martínez‐González, Jose, Rodríguez, Cristina, Cachofeiro, Victoria, Salaices, Mercedes, Briones, Ana M.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.06.2022
• Subjects: Adipose tissue; Adipose Tissue - metabolism; adipose tissue alterations; Animals; Aorta; Arteries; Blood pressure; Body fat; Body weight gain; Cardiomyocytes; Colorimetry; Diet, High-Fat; Female; Fibrosis; Gene expression; Glucose - metabolism; Glucose tolerance; High fat diet; Humans; Hypertrophy; Inflammation; Inflammation - metabolism; Insulin; Insulin Resistance; Lipids; Male; Metabolism; Mice; Mice, Inbred C57BL; mPGES‐1; Obesity; Obesity - metabolism; Prostaglandin E; Prostaglandin E2; Prostaglandin-E Synthases - genetics; Prostaglandin-E Synthases - metabolism; Structure-function relationships; vascular function and remodelling; adipose tissue alterations; mPGES-1; vascular function and remodelling; inflammation; obesity

Background and Purpose Microsomal prostaglandin E synthase‐1 (mPGES‐1) is an inducible isomerase responsible for prostaglandin E2 production in inflammatory conditions. We evaluated the role of mPGES‐1 in the development and the metabolic and cardiovascular alterations of obesity. Experimental Appro...