Simulated microgravity attenuates skin wound healing by inhibiting dermal fibroblast migration via F‐actin/YAP signaling pathway

• Published in: Journal of cellular physiology Vol. 238; no. 12; pp. 2751 - 2764
• Main Authors: Zhou, Yuhao, Lv, Wenjun, Peng, Xiufen, Cheng, Yansiwei, Tu, Yun, Song, Guanbin, Luo, Qing
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2023
• Subjects: Actin; Actins - metabolism; Animals; Astronauts; Cell Line; Female; Fibroblasts; Fibroblasts - metabolism; F‐actin; Gravity; Homeostasis; Humans; Jasplakinolide; Lysophosphatidic acid; Maintenance; Microgravity; migration; Polymerization; Rats; Rats, Sprague-Dawley; Signal Transduction; simulated microgravity; Skin; Skin - metabolism; Therapeutic targets; Weightlessness; Wound Healing; YAP; Yes-associated protein; migration; YAP; wound healing; F-actin; simulated microgravity

Skin and its cell components continuously subject to extrinsic and intrinsic mechanical forces and are mechanical sensitive. Disturbed mechanical homeostasis may lead to changes in skin functions. Gravity is the integral mechanical force on the earth, however, how gravity contributes to the maintena...