Transforming growth factor beta 1 polymorphisms and haplotypes associated with breast cancer susceptibility: A case-control study in Tunisian women

• Published in: Tumor biology Vol. 41; no. 8; p. 1010428319869096
• Main Authors: Hadj-Ahmed, Mariem, Ghali, Rabeb M, Bouaziz, Hanen, Habel, Azza, Stayoussef, Mouna, Ayedi, Mouna, Hachiche, Monia, Rahal, Khaled, Yacoubi-Loueslati, Besma, Almawi, Wassim Y
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.08.2019; Sage Publications Ltd; SAGE Publishing
• Subjects: Alleles; Breast cancer; Breast Neoplasms - genetics; Female; Gene frequency; Gene Frequency - genetics; Genetic Predisposition to Disease - genetics; Growth factors; Haplotypes; Haplotypes - genetics; Humans; Menarche; Menopause; Menstruation; Metastases; Middle Aged; Pathogenesis; Polymorphism, Single Nucleotide - genetics; Single-nucleotide polymorphism; Transforming Growth Factor beta1 - genetics; Transforming growth factor-b1; Tunisia; Womens health; Tunisia; genotypes; haplotypes; Breast cancer; transforming growth factor–β1

Variable association of transforming growth factor beta 1 (TGFβ1) in breast cancer (BC) pathogenesis was documented, and the contribution of specific TGFB1 polymorphisms to the progression of BC and associated features remains poorly understood. We investigated the contribution of TGFB1 rs1800469, r...