Preimplantation embryo gene expression: 56 years of discovery, and counting

• Published in: Molecular reproduction and development Vol. 90; no. 4; pp. 169 - 200
• Main Author: Latham, Keith E.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2023
• Subjects: Animal models; Animals; Blastocyst - physiology; Cell culture; embryo; Embryo, Mammalian; Embryonic Development - genetics; Embryos; Enzymatic activity; Gametes; Gene Expression; Gene Expression Regulation, Developmental; Gene regulation; Genetic screening; genome activation; Livestock; oocyte; Oocytes; Oocytes - physiology; Protein biosynthesis; Reproduction; transcription; translation; genome activation; translation; embryo; oocyte; transcription; gene regulation

The biology of preimplantation embryo gene expression began 56 years ago with studies of the effects of protein synthesis inhibition and discovery of changes in embryo metabolism and related enzyme activities. The field accelerated rapidly with the emergence of embryo culture systems and progressive...