Hemoglobin-based oxygen carrier provides heterogeneous microvascular oxygenation in heart and gut after hemorrhage in pigs

• Published in: The journal of trauma Vol. 55; no. 6; p. 1111
• Main Authors: van Iterson, Mat, Siegemund, Martin, Burhop, Kenneth, Ince, Can
• Format: Journal Article
• Language: English
• Published: United States 01.12.2003
• Subjects: Analysis of Variance; Animals; Aspirin - analogs & derivatives; Aspirin - pharmacology; Aspirin - therapeutic use; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Monitoring; Female; Fluid Therapy - methods; Hemoglobins - pharmacology; Hemoglobins - therapeutic use; Hydroxyethyl Starch Derivatives - administration & dosage; Hydroxyethyl Starch Derivatives - pharmacology; Ileum - blood supply; Ileum - chemistry; Ileum - drug effects; Ileum - metabolism; Intestinal Mucosa - blood supply; Intestinal Mucosa - chemistry; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; Microcirculation - drug effects; Oxygen - analysis; Oxygen - metabolism; Oxygen Consumption - drug effects; Pericardium - chemistry; Pericardium - drug effects; Pericardium - metabolism; Plasma Substitutes - administration & dosage; Plasma Substitutes - pharmacology; Resuscitation - methods; Shock, Hemorrhagic - drug therapy; Shock, Hemorrhagic - metabolism; Shock, Hemorrhagic - physiopathology; Swine; Time Factors

In this study, the hypothesis was tested that resuscitation with hemoglobin-based oxygen carriers (HBOCs) affects the oxygenation of the microcirculation differently between and within organs. To this end, we tested the influence of the volume of an HBOC on the microcirculatory oxygenation of the he...