Detection of cerebral NAD+ in humans at 7T

• Published in: Magnetic resonance in medicine Vol. 78; no. 3; pp. 828 - 835
• Main Authors: Graaf, Robin A., Feyter, Henk M., Brown, Peter B., Nixon, Terence W., Rothman, Douglas L., Behar, Kevin L.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2017
• Subjects: 1H‐MRS; 31P‐MRS; 7 Tesla; Adenine; Adult; Algorithms; Brain; Brain - diagnostic imaging; Brain - metabolism; Brain Chemistry - physiology; Female; human brain; Humans; Image Processing, Computer-Assisted; In vivo methods and tests; Magnetic Resonance Imaging - methods; Male; Medicine; Metabolism; Middle Aged; NAD; NAD - analysis; NAD - chemistry; NAD - metabolism; NADH; Nicotinamide; Nicotinamide adenine dinucleotide; NMR; Nuclear magnetic resonance; Signal Processing, Computer-Assisted; Uridine; NAD; 1H-MRS; human brain; 31P-MRS; 7 Tesla

Purpose To develop 1H‐based MR detection of nicotinamide adenine dinucleotide (NAD+) in the human brain at 7T and validate the 1H results with NAD+ detection based on 31P‐MRS. Methods 1H‐MR detection of NAD+ was achieved with a one‐dimensional double‐spin‐echo method on a slice parallel to the surfa...