Quantitative PCR of string‐test collected gastric material: A feasible approach to detect Helicobacter pylori and its resistance against clarithromycin and levofloxacin for susceptibility‐guided therapy

• Published in: Helicobacter (Cambridge, Mass.) Vol. 28; no. 4; pp. e12985 - n/a
• Main Authors: Han, Xinyuan, Yu, Xiqiu, Gao, Xiaojuan, Wang, Xiangyu, Tay, Chin Yen, Wei, Xiaolan, Lai, Bing, Marshall, Barry J., Zhang, Xiuming, Chua, Eng Guan
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2023
• Subjects: Amoxicillin - therapeutic use; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotics; Bismuth; Bismuth - therapeutic use; Clarithromycin; Clarithromycin - pharmacology; Clarithromycin - therapeutic use; diagnosis; Drug Therapy, Combination; Empirical analysis; Eradication; Health services; Helicobacter Infections - diagnosis; Helicobacter Infections - drug therapy; Helicobacter pylori; Helicobacter pylori - genetics; Hospitals; Humans; Levofloxacin; Levofloxacin - pharmacology; Levofloxacin - therapeutic use; Patients; Polymerase Chain Reaction; quantitative PCR; Retrospective Studies; string test; Strings; Success; Susceptibility; susceptibility‐guided therapy; Therapy; Treatment Outcome; Urea; diagnosis; string test; Helicobacter pylori; quantitative PCR; susceptibility-guided therapy

Background As the reduced eradication rate of Helicobacter pylori (H. pylori), we introduced string‐test and quantitative PCR (qPCR) for susceptibility‐guided therapy innovatively. The practicality of the string test was evaluated. Methods It was an open‐label, non‐randomized, parallel, single‐cente...