Transfer of the Dual Orexin Receptor Antagonist Daridorexant into Breast Milk of Healthy Lactating Women

• Published in: Journal of clinical pharmacology Vol. 64; no. 10; pp. 1278 - 1287
• Main Authors: Kaufmann, Priska, Muehlan, Clemens, Anliker‐Ort, Marion, Sabattini, Giancarlo, Siebers, Nicholas, Dingemanse, Jasper
• Format: Journal Article
• Language: English
• Published: England 01.10.2024
• Subjects: Administration, Oral; Adult; breast milk; daridorexant; Female; Humans; Imidazoles - administration & dosage; Imidazoles - blood; Imidazoles - pharmacokinetics; insomnia; lactation; Lactation - metabolism; Milk, Human - chemistry; Milk, Human - metabolism; orexin; Orexin Receptor Antagonists - administration & dosage; Orexin Receptor Antagonists - pharmacokinetics; pharmacokinetics; Pyrrolidines; Young Adult; pharmacokinetics; breast milk; daridorexant; orexin; lactation; insomnia

The novel dual orexin receptor antagonist daridorexant was approved in 2022 for the treatment of adult patients with insomnia. The aim of this post‐marketing study was to measure daridorexant and its major metabolites in breast milk and plasma of 10 healthy lactating subjects. This single‐center, op...