Molecular Programming of Perivascular Stem Cell Precursors

• Published in: Stem cells (Dayton, Ohio) Vol. 36; no. 12; pp. 1890 - 1904
• Main Authors: Yianni, Val, Sharpe, Paul T.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.12.2018; Oxford University Press
• Subjects: Adipogenesis; Adult stem cells; Animals; Biocompatibility; Biomedical materials; Bone marrow; Cbfa-1 protein; Cell culture; Cell Differentiation; Chondrogenesis; Chromatin; Dental pulp; Differentiation (biology); Epigenetics; Genes; Histones; Incisors; Insertion; Mesenchymal Stem Cells - metabolism; Mesenchyme; Mice; MSC; Myogenesis; Pericyte; Pericytes; Pericytes - cytology; Pericytes - metabolism; Polycomb group proteins; Populations; Precursors; Stem cell transplantation; Stem cells; Tissues; Transcription; Transcriptomics; Epigenetics; Pericyte; Adult stem cells; MSC; Transcriptomics

Pericytes have been shown to act as precursors of resident adult stem cells in stromal tissues in vivo. When expanded in vitro these cells are capable of giving rise to multiple mesenchymal cell types, irrespective of their tissue of origin. This phenomenon of multi‐lineage differentiation is only o...