Development of a voided urine assay for detecting prostate cancer non‐invasively: a pilot study

• Published in: BJU international Vol. 119; no. 6; pp. 885 - 895
• Main Authors: Trabulsi, Edouard J., Tripathi, Sushil K., Gomella, Leonard, Solomides, Charalambos, Wickstrom, Eric, Thakur, Mathew L.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.06.2017
• Subjects: Adult; Benign; Crystals; Female; Flow cytometry; Humans; Hyperplasia; imaging prostate cancer; Male; Malignancy; Nuclei; optical imaging; PCSM; Pilot Projects; Prostate cancer; ProstateCancer; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - urine; Receptors, Vasoactive Intestinal Peptide, Type II - analysis; Receptors, Vasoactive Intestinal Polypeptide, Type I - analysis; targeting VPAC receptors; Urinalysis - methods; urinary assay; Urine; Young Adult; PCSM; urinary assay; ProstateCancer; imaging prostate cancer; targeting VPAC receptors; optical imaging

Objective To validate a hypothesis that prostate cancer can be detected non‐invasively by a simple and reliable assay by targeting genomic VPAC receptors expressed on malignant prostate cancer cells shed in voided urine. Patients/Subjects and Methods VPAC receptors were targeted with a specific biom...