Chronic lymphocytic leukemia patients with IGH translocations are characterized by a distinct genetic landscape with prognostic implications

• Published in: International journal of cancer Vol. 147; no. 10; pp. 2780 - 2792
• Main Authors: Pérez‐Carretero, Claudia, Hernández‐Sánchez, María, González, Teresa, Quijada‐Álamo, Miguel, Martín‐Izquierdo, Marta, Hernández‐Sánchez, Jesús‐María, Vidal, María‐Jesús, Coca, Alfonso García, Aguilar, Carlos, Vargas‐Pabón, Manuel, Alonso, Sara, Sierra, Magdalena, Rubio‐Martínez, Araceli, Dávila, Julio, Díaz‐Valdés, José R., Queizán, José‐Antonio, Hernández‐Rivas, José‐Ángel, Benito, Rocío, Rodríguez‐Vicente, Ana E., Hernández‐Rivas, Jesús‐María
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 15.11.2020; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Aged, 80 and over; Cancer; Cdc4 protein; chromosomal translocations; Chromosome 14; Chromosome translocations; Chromosomes, Human, Pair 13 - genetics; Chromosomes, Human, Pair 14 - genetics; Chronic lymphocytic leukemia; clinical molecular genetics; Cytogenetics; Female; Fluorescence in situ hybridization; Gene Regulatory Networks; Genetic Predisposition to Disease; Heavy chains; High-Throughput Nucleotide Sequencing - methods; high‐throughput sequencing; Humans; Immunoglobulin Heavy Chains - genetics; Immunoglobulins; In Situ Hybridization, Fluorescence; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell - genetics; Lymphatic leukemia; Lymphoma; Male; Medical research; Middle Aged; Mutation; p53 Protein; Prognosis; prognostic biomarkers; Risk factors; Sequence Analysis, DNA; Translocation, Genetic; prognostic biomarkers; clinical molecular genetics; chromosomal translocations; chronic lymphocytic leukemia; cytogenetics; high-throughput sequencing

Chromosome 14q32 rearrangements/translocations involving the immunoglobulin heavy chain (IGH) are rarely detected in chronic lymphocytic leukemia (CLL). The prognostic significance of the IGH translocation is controversial and its mutational profile remains unknown. Here, we present for the first ti...