High‐fat and high‐sucrose (western) diet induces steatohepatitis that is dependent on fructokinase

• Published in: Hepatology (Baltimore, Md.) Vol. 58; no. 5; pp. 1632 - 1643
• Main Authors: Ishimoto, Takuji, Lanaspa, Miguel A., Rivard, Christopher J., Roncal‐Jimenez, Carlos A., Orlicky, David J., Cicerchi, Christina, McMahan, Rachel H., Abdelmalek, Manal F., Rosen, Hugo R., Jackman, Matthew R., MacLean, Paul S., Diggle, Christine P., Asipu, Aruna, Inaba, Shinichiro, Kosugi, Tomoki, Sato, Waichi, Maruyama, Shoichi, Sánchez‐Lozada, Laura G., Sautin, Yuri Y., Hill, James O., Bonthron, David T., Johnson, Richard J.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2013
• Subjects: Animals; Diet; Diet, High-Fat; Energy Intake; Fatty Liver - etiology; Fructokinases - physiology; Fructose - metabolism; Hepatology; Liver - metabolism; Liver - pathology; Liver cirrhosis; Mice; Mice, Inbred C57BL; Rodents; Sucrose; Sucrose - administration & dosage; Weight Gain

Fructose intake from added sugars has been implicated as a cause of nonalcoholic fatty liver disease. Here we tested the hypothesis that fructose may interact with a high‐fat diet to induce fatty liver, and to determine if this was dependent on a key enzyme in fructose metabolism, fructokinase. Wild...