Changes in lipidomic profile of aqueous humour in Fuchs endothelial dystrophy

• Published in: Acta ophthalmologica (Oxford, England) Vol. 95; no. 7; pp. 727 - 732
• Main Authors: Cabrerizo, Javier, Urcola, Javier Aritz, Vecino, Elena, Melles, Gerrit
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.11.2017
• Subjects: Apoptosis; Aqueous Humor - metabolism; aqueous humour; Biomarkers - analysis; Chromatography; Chromatography, Liquid; Cornea; Corneal dystrophy; corneal endothelium; Corneal transplantation; Dystrophy; Endothelial cells; Esters; Female; Fuchs endothelial dystrophy; Fuchs' Endothelial Dystrophy - metabolism; Fuchs' Endothelial Dystrophy - pathology; Humans; Lipid composition; Lipid Metabolism; Lipids; Lipids - analysis; Liquid chromatography; Male; Mass spectroscopy; Middle Aged; Oxidative Stress; Physicochemical properties; Sphingolipids; Surgery; lipids; corneal endothelium; aqueous humour; Fuchs endothelial dystrophy

Purpose To identify and determine differences in lipid profile of aqueous humour (AH) in patients with Fuchs endothelial corneal dystrophy (FECD). Methods Lipidomic profile of eight AH samples of FECD patients and 10 control samples was analysed. Patients with previous history of anterior segment su...