Comparison of multiple electrode aggregometry with lumi‐aggregometry for the diagnosis of patients with mild bleeding disorders

• Published in: Journal of thrombosis and haemostasis Vol. 15; no. 10; pp. 2045 - 2052
• Main Authors: Al Ghaithi, R., Drake, S., Watson, S. P., Morgan, N. V., Harrison, P.
• Format: Journal Article
• Language: English
• Published: England Elsevier Limited 01.10.2017
• Subjects: Adolescent; Adult; Aged; Antiplatelet therapy; Arachidonic acid; Aspirin; Bleeding; Blood; Blood Coagulation Disorders - blood; Blood Coagulation Disorders - diagnosis; Blood platelets; Case-Control Studies; Child; Child, Preschool; Clopidogrel; Collagen; Diagnosis; Electric Impedance; Electrical impedance; Electrodes; Epinephrine; Female; Genotyping; Hemophilia; Humans; Light; light transmission lumi‐aggregometry; Male; Middle Aged; mild bleeding disorders; multiple electrode aggregometry; Phenotyping; Platelet Aggregation; Platelet Count; platelet function defects; Platelet Function Tests - instrumentation; Platelet Function Tests - methods; Predictive Value of Tests; Proteinase-activated receptor 1; Reproducibility of Results; Ristocetin; Secretion; Severity of Illness Index; United Kingdom; Young Adult; United Kingdom; light transmission lumi-aggregometry; mild bleeding disorders; multiple electrode aggregometry; platelet function defects; platelet aggregation

Essentials There is a clinical need for new technologies to measure platelet function in whole blood. Mild bleeding disorders were evaluated using multiple electrode aggregometry (MEA). MEA is insensitive at detecting patients with mild platelet function and secretion defects. More studies are requi...