Regional brain volumetry and brain function in severely brain‐injured patients

• Published in: Annals of neurology Vol. 83; no. 4; pp. 842 - 853
• Main Authors: Annen, Jitka, Frasso, Gianluca, Crone, Julia Sophia, Heine, Lizette, Di Perri, Carol, Martial, Charlotte, Cassol, Helena, Demertzi, Athena, Naccache, Lionel, Laureys, Steven
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2018
• Subjects: Adult; Analysis of Variance; Atrophy; Atrophy - etiology; Brain; Brain - diagnostic imaging; Brain Injuries - complications; Brain Injuries - diagnostic imaging; Classification; Confidence intervals; Consciousness; Cortex; Emission analysis; Female; Fluorodeoxyglucose F18 - metabolism; Glasgow Outcome Scale; Gray Matter - diagnostic imaging; Humans; Image Processing, Computer-Assisted; Injuries; Magnetic Resonance Imaging; Male; Medical imaging; Middle Aged; Neural networks; Neuroimaging; Neurology; Patients; Persistent Vegetative State - diagnostic imaging; Persistent Vegetative State - etiology; Positron emission; Positron emission tomography; Retrospective Studies; ROC Curve; Sleep and wakefulness; Substantia alba; Substantia grisea; Wakefulness; White Matter - diagnostic imaging; Young Adult

Objective The relationship between residual brain tissue in patients with disorders of consciousness (DOC) and the clinical condition is unclear. This observational study aimed to quantify gray (GM) and white matter (WM) atrophy in states of (altered) consciousness. Methods Structural T1‐weighted ma...