Cerebrospinal fluid, brain, and spinal cord levels of L‐aspartate signal excitatory neurotransmission abnormalities in multiple sclerosis patients and experimental autoimmune encephalomyelitis mouse model

• Published in: Journal of neurochemistry Vol. 166; no. 3; pp. 534 - 546
• Main Authors: Errico, Francesco, Gilio, Luana, Mancini, Andrea, Nuzzo, Tommaso, Bassi, Mario Stampanoni, Bellingacci, Laura, Buttari, Fabio, Dolcetti, Ettore, Bruno, Antonio, Galifi, Giovanni, Furlan, Roberto, Finardi, Annamaria, Di Maio, Anna, Di Filippo, Massimiliano, Centonze, Diego, Usiello, Alessandro
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2023
• Subjects: Abnormalities; Amino acids; aspartate; Autoimmune diseases; Biomarkers; Cerebellum; Cerebrospinal fluid; Correlation; Cytokines; Enantiomers; Encephalomyelitis; Eotaxin; Excitatory amino acids; Experimental allergic encephalomyelitis; Glutamatergic transmission; Inflammation; Multiple sclerosis; Neurological diseases; Neurotransmission; NMDA receptors; Spinal cord; Synaptic transmission; NMDA receptors; aspartate; inflammation; multiple sclerosis; cerebrospinal fluid

The neuroinflammatory process characterizing multiple sclerosis (MS) is associated with changes in excitatory synaptic transmission and altered central concentrations of the primary excitatory amino acid, L‐glutamate (L‐Glu). Recent findings report that cerebrospinal fluid (CSF) levels of L‐Glu posi...