Population Pharmacokinetic Analysis of Recombinant Factor VIII Fc Fusion Protein in Subjects With Severe Hemophilia A: Expanded to Include Pediatric Subjects - Katragadda, Suresh; Neelakantan, Srividya; Diao, Lei; Wong, Nancy (Journal of clinical pharmacology, 2021)
Keywords: Adolescent; Age Factors; Body Weight; Child; Computer Simulation; Drug Dosage Calculations; Factor VIII - administration & dosage; Factor VIII - pharmacokinetics; Half-Life; Hemophilia A - drug therapy; Humans; Immunoglobulin Fc Fragments - administration & dosage; Male; Metabolic Clearance Rate; Models, Biological; Patient Acuity; Recombinant Fusion Proteins - administration & dosage; Recombinant Fusion Proteins - pharmacokinetics; von Willebrand Factor - drug effects; rFVIIIFc protein; adolescent; adult; child; pharmacokinetic modeling