Precision Dosing for Tacrolimus Using Genotypes and Clinical Factors in Kidney Transplant Recipients of European Ancestry

• Published in: Journal of clinical pharmacology Vol. 61; no. 8; p. 1035
• Main Authors: Al-Kofahi, Mahmoud, Oetting, William S, Schladt, David P, Remmel, Rory P, Guan, Weihua, Wu, Baolin, Dorr, Casey R, Mannon, Roslyn B, Matas, Arthur J, Israni, Ajay K, Jacobson, Pamala A
• Format: Journal Article
• Language: English
• Published: England 01.08.2021
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Comorbidity; Cytochrome P-450 CYP3A - genetics; Drug Interactions; Female; Genotype; Humans; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - pharmacokinetics; Kidney Transplantation; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Tacrolimus - administration & dosage; Tacrolimus - pharmacokinetics; Transplant Recipients; White People; Young Adult; kidney transplant; genomics; pharmacogenomics; tacrolimus; population pharmacokinetics

Genetic variation in the CYP3A4 and CYP3A5 (CYP3A4/5) genes, which encode the key enzymes in tacrolimus metabolism, is associated with tacrolimus clearance and dose requirements. Tacrolimus has a narrow therapeutic index with high intra- and intersubject variability, in part because of genetic varia...