Relative Bioavailability and Food Effect of Asciminib Pediatric Mini‐tablet Formulation Compared to the Reference Tablet Formulation in Healthy Adult Participants

• Published in: Clinical pharmacology in drug development Vol. 12; no. 5; pp. 484 - 492
• Main Authors: Hoch, Matthias, Bebrevska, Lidiya, Singh, Namrata, Hourcade‐Potelleret, Florence
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2023
• Subjects: Adult; asciminib; Bioavailability; Biological Availability; Child; chronic myeloid leukemia; Cross-Over Studies; Food; food effect; Humans; pediatric formulation; Pediatrics; Pyrazoles - pharmacokinetics; Tablets; chronic myeloid leukemia; food effect; bioavailability; pediatric formulation; asciminib

Asciminib, a first‐in‐class allosteric BCR::ABL1 inhibitor that works by Specifically Targeting the ABL Myristoyl Pocket (STAMP) is used in the treatment of chronic myeloid leukemia. We describe a randomized, single‐dose, open‐label, four‐period crossover study in healthy adult participants (N = 24)...