Deciphering the folate puzzle: Unraveling the impact of genetic variations and metabolites on cancer risk

• Published in: International journal of cancer Vol. 155; no. 7; pp. 1225 - 1236
• Main Authors: Liu, Tong, Liu, Chen‐An, Wei, Ya‐Ping, Song, Meng‐Meng, Zhang, Qi, Song, Yun, Chen, Ping, Liu, Li‐Shun, Wang, Bin‐Yan, Shi, Han‐Ping
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.10.2024; Wiley Subscription Services, Inc
• Subjects: 5‐MTHF; Adult; Adults; Aged; Cancer; Case-Control Studies; Epidemiology; Female; folate; Folic acid; Folic Acid - blood; Folic Acid - metabolism; Gene polymorphism; Genetic diversity; Genetic factors; Genetic Predisposition to Disease; Genotype; Health risks; Humans; Hypertension; Male; Metabolism; Metabolites; Methylenetetrahydrofolate reductase; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; MTHFR C677T; Neoplasms - epidemiology; Neoplasms - genetics; Polymorphism; Polymorphism, Single Nucleotide; Regression analysis; Risk Factors; Serum levels; Statistical analysis; Statistical models; tetrahydrofolate; Tetrahydrofolates; Vitamin B; MTHFR C677T; folate; cancer; 5‐MTHF; tetrahydrofolate

The C677T polymorphism in the MTHFR gene and its role in folate metabolism, impacting serum folate metabolites like THF and 5‐MTHF, is a critical but underexplored area in cancer research. This nested case–control study utilized data from CHHRS, involving 87,492 hypertensive adults without prior can...