Combined effects of aflatoxin B1 and deoxynivalenol on the expression of glutathione redox system regulatory genes in common carp

• Published in: Journal of animal physiology and animal nutrition Vol. 104; no. 5; pp. 1531 - 1539
• Main Authors: Kövesi, Benjamin, Pelyhe, Csilla, Zándoki, Erika, Mézes, Miklós, Balogh, Krisztián
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.09.2020
• Subjects: Aflatoxin B1; Aflatoxins; antioxidant defence system; Carp; common carp; Cyprinus carpio; Deoxynivalenol; Exposure; Free radicals; Gene expression; Genes; Glutathione; Glutathione peroxidase; Glutathione reductase; Kidneys; Liver; Mycotoxins; NRF2 protein; Oxidative stress; Peroxidase; Reactive oxygen species; Reductases; Signal transduction; Spleen; Transcription factors; deoxynivalenol; aflatoxin B1; antioxidant defence system; gene expression; common carp; glutathione peroxidase

The purpose of the present study was to evaluate the short‐term effects of aflatoxin B1 (AFB1) and deoxynivalenol (DON) exposure on the expression of the genes encoding the glutathione redox system glutathione peroxidase 4a (gpx4a), glutathione peroxidase 4b (gpx4b), glutathione synthetase (gss) and...