Selective Decrease in Allodynia With High‐Frequency Neuromodulation via High‐Electrode‐Count Intrafascicular Peripheral Nerve Interface After Brachial Plexus Injury

• Published in: Neuromodulation (Malden, Mass.) Vol. 22; no. 5; pp. 597 - 606
• Main Authors: Duncan, Christopher C., Kluger, David T., Davis, Tyler S., Warren, David J., Page, David M., Hutchinson, Douglas T., Clark, Gregory A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Limited 01.07.2019
• Subjects: Aged; Allodynia; Anesthetics; Brachial plexus; Brachial Plexus - injuries; Brachial Plexus - physiology; Chronic pain; Electrodes; Electrodes, Implanted; Humans; Hyperalgesia - diagnostic imaging; Hyperalgesia - physiopathology; Hyperalgesia - therapy; Male; Median nerve; Median Nerve - physiology; nerve block; Nervous system; Neuromodulation; neuropathic pain; Pain; Pain perception; peripheral nerve stimulation; Peripheral nerves; Peripheral Nerves - physiology; Transcutaneous Electric Nerve Stimulation - instrumentation; Transcutaneous Electric Nerve Stimulation - methods; Allodynia; neuromodulation; neuropathic pain; nerve block; peripheral nerve stimulation

Objectives Kilohertz high‐frequency alternating current (KHFAC) electrical nerve stimulation produces a reversible nerve block in peripheral nerves in human patients with chronic pain pathologies. Although this stimulation methodology has been verified with nonselective extrafascicular electrodes, t...