High human cytomegalovirus DNAemia early post‐transplantation associates with irreversible and progressive loss of renal function – a retrospective study

• Published in: Transplant international Vol. 30; no. 8; pp. 817 - 826
• Main Authors: Lollinga, Wouter T., Rurenga‐Gard, Lilli, Doesum, Willem, Bergen, Rik, Diepstra, Arjan, Vonk, Judith M., Riezebos‐Brilman, Annelies, Niesters, H. G. M., Son, Willem J., Born, Jacob, Sanders, Jan‐Stephan
• Format: Journal Article
• Language: English
• Published: England Frontiers Media SA 01.08.2017
• Subjects: Adult; Cytomegalovirus; Cytomegalovirus - genetics; Cytomegalovirus Infections - blood; Cytomegalovirus Infections - etiology; Cytomegalovirus Infections - virology; DNA, Viral - blood; DNA, Viral - genetics; Epidermal growth factor receptors; estimated glomerular filtration rate; Female; Glomerular Filtration Rate; human cytomegalovirus; Humans; Infections; Kidney - physiopathology; Kidney transplantation; Kidney Transplantation - adverse effects; Male; Middle Aged; Peak load; Preempting; Regression analysis; Renal function; Retrospective Studies; Statistical analysis; Time Factors; Transplantation; Transplants & implants; viral infection; Viral infections; Viral Load; Viremia - blood; Viremia - etiology; Viremia - virology; renal function; viral infection; estimated glomerular filtration rate; human cytomegalovirus; kidney transplantation

Summary Transplant recipients are prone to viral infections, which could affect renal transplantation outcome. Our aim was to assess the effects of early human cytomegalovirus (CMV) DNAemia on transplant renal function. A total of 264 (age 50.9 ± 13.5; male 55%) renal transplantation recipients unde...