Randomised clinical trial: evaluation of the efficacy of mesalazine (mesalamine) suppositories in patients with ulcerative colitis and active rectal inflammation – a placebo‐controlled study

• Published in: Alimentary pharmacology & therapeutics Vol. 38; no. 3; pp. 264 - 273
• Main Authors: Watanabe, M., Nishino, H., Sameshima, Y., Ota, A., Nakamura, S., Hibi, T.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.08.2013
• Subjects: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Asian Continental Ancestry Group; Biological and medical sciences; Colitis, Ulcerative - drug therapy; Digestive system; Double-Blind Method; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Inflammation; Male; Medical sciences; Mesalamine - administration & dosage; Mesalamine - adverse effects; Middle Aged; Other diseases. Semiology; Pharmacology. Drug treatments; Proctitis - drug therapy; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Suppositories - administration & dosage; Suppositories - adverse effects; Treatment Outcome; Young Adult; Human; Prostaglandin-endoperoxide synthase; Evaluation; Enzyme; Treatment efficiency; Enzyme inhibitor; Inflammation; Rectal administration; Inflammatory disease; Non steroidal antiinflammatory agent; Analgesic; Mesalazine; Placebo; Rectum; Dosage form; Antipyretic; Digestive diseases; Intestinal disease; Clinical trial; Oxidoreductases; Salicylates; Suppository; Ulcerative colitis

Summary Background Mesalazine suppositories are recommended and widely used as the standard therapy in induction and maintenance of remission for proctitis. Aim To evaluate the efficacy of mesalazine suppositories in patients with ulcerative colitis (UC) and rectal inflammation; and in patient group...