Multigene panel testing results in patients with multiple breast cancer primaries

• Published in: The breast journal Vol. 26; no. 7; pp. 1337 - 1342
• Main Authors: Corredor, Jessica, Woodson, Ashley H., Gutierrez Barrera, Angelica, Arun, Banu
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2020
• Subjects: Age; BRCA1 protein; BRCA2 protein; Breast cancer; breast cancer predisposition genes; Diagnosis; Genes; Genetic screening; genetics; MSH2 protein; MSH6 protein; multiple breast primaries; Mutation; p53 Protein; panel testing; PTEN protein; panel testing; genetics; breast cancer predisposition genes; multiple breast primaries

Currently, the NCCN guidelines recommend testing of BRCA1 and BRCA2 for females with multiple breast primaries, if her first diagnosis was ≤50 years old. With the increase in uptake of multigene panels, testing for genes outside of BRCA1 and BRCA2 has become more prevalent. This study looked at a si...