Early Outcomes in Children With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 69; no. 7; pp. 1470 - 1479
• Main Authors: Morishita, Kimberly A., Moorthy, Lakshmi N., Lubieniecka, Joanna M., Twilt, Marinka, Yeung, Rae S. M., Toth, Mary B., Shenoi, Susan, Ristic, Goran, Nielsen, Susan M., Luqmani, Raashid A., Li, Suzanne C., Lee, Tzielan, Lawson, Erica F., Kostik, Mikhail M., Klein‐Gitelman, Marisa, Huber, Adam M., Hersh, Aimee O., Foell, Dirk, Elder, Melissa E., Eberhard, Barbara A., Dancey, Paul, Charuvanij, Sirirat, Benseler, Susanne M., Cabral, David A.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2017
• Subjects: Adolescent; Adrenal Cortex Hormones - therapeutic use; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - complications; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - drug therapy; Antineutrophil cytoplasmic antibodies; Azathioprine - therapeutic use; Child; Children; Churg-Strauss syndrome; Cohort Studies; Corticosteroids; Cyclophosphamide - therapeutic use; Damage; Diagnosis; Dosage; Female; Follow-Up Studies; Glomerulonephritis; Humans; Immunosuppressive Agents - therapeutic use; Kidney Diseases - drug therapy; Kidney Diseases - etiology; Leukocytes (eosinophilic); Lung Diseases - drug therapy; Lung Diseases - etiology; Male; Methotrexate - therapeutic use; Mycophenolic Acid - therapeutic use; Patients; Pediatrics; Prospective Studies; Recurrence; Registries; Remission; Remission Induction; Retrospective Studies; Rituximab - therapeutic use; Vasculitis; Wegener's granulomatosis

Objective To characterize the early disease course in childhood‐onset antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) and the 12‐month outcomes in children with AAV. Methods Eligible subjects were children entered into the Pediatric Vasculitis Initiative study who were diagnos...