Prognostic value of the 8th edition American Joint Commission Cancer nodal staging system for patients with head and neck cutaneous squamous cell carcinoma: A multi‐institutional study
Background The 8th edition American Joint Committee on Cancer staging manual (AJCC8) introduced a separate staging system for head and neck cutaneous squamous cell carcinoma (HNcSCC) which parallels mucosal SCC and incorporates extranodal extension (ENE). This study aims to evaluate its prognostic u...
Saved in:
Published in | Head & neck Vol. 43; no. 2; pp. 558 - 567 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Hoboken, USA
John Wiley & Sons, Inc
01.02.2021
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Background
The 8th edition American Joint Committee on Cancer staging manual (AJCC8) introduced a separate staging system for head and neck cutaneous squamous cell carcinoma (HNcSCC) which parallels mucosal SCC and incorporates extranodal extension (ENE). This study aims to evaluate its prognostic utility.
Methods
Univariate analysis of 1146 patients with metastatic HNcSCC from four Australian cancer centers was performed according to both AJCC 7th (AJCC7) and the 8th editions.
Results
AJCC8 increased classification of 924 (80.6%) patients to either pN2a or pN3b and 341 patients (29.8%) from stage III to IV compared to AJCC7. The disease‐specific survival (DSS) was not significantly different between pN1, pN2 or pN3a categories per AJCC8. Estimates of model performance for the AJCC8 pN staging revealed modest predictive capacity (Harrell's C of 0.62 for DSS).
Conclusions
The risk stratification according to pN classification of AJCC8 staging system performed poorly as a prognostic indicator. |
---|---|
AbstractList | The 8th edition American Joint Committee on Cancer staging manual (AJCC8) introduced a separate staging system for head and neck cutaneous squamous cell carcinoma (HNcSCC) which parallels mucosal SCC and incorporates extranodal extension (ENE). This study aims to evaluate its prognostic utility.
Univariate analysis of 1146 patients with metastatic HNcSCC from four Australian cancer centers was performed according to both AJCC 7th (AJCC7) and the 8th editions.
AJCC8 increased classification of 924 (80.6%) patients to either pN2a or pN3b and 341 patients (29.8%) from stage III to IV compared to AJCC7. The disease-specific survival (DSS) was not significantly different between pN1, pN2 or pN3a categories per AJCC8. Estimates of model performance for the AJCC8 pN staging revealed modest predictive capacity (Harrell's C of 0.62 for DSS).
The risk stratification according to pN classification of AJCC8 staging system performed poorly as a prognostic indicator. Background The 8th edition American Joint Committee on Cancer staging manual (AJCC8) introduced a separate staging system for head and neck cutaneous squamous cell carcinoma (HNcSCC) which parallels mucosal SCC and incorporates extranodal extension (ENE). This study aims to evaluate its prognostic utility. Methods Univariate analysis of 1146 patients with metastatic HNcSCC from four Australian cancer centers was performed according to both AJCC 7th (AJCC7) and the 8th editions. Results AJCC8 increased classification of 924 (80.6%) patients to either pN2a or pN3b and 341 patients (29.8%) from stage III to IV compared to AJCC7. The disease‐specific survival (DSS) was not significantly different between pN1, pN2 or pN3a categories per AJCC8. Estimates of model performance for the AJCC8 pN staging revealed modest predictive capacity (Harrell's C of 0.62 for DSS). Conclusions The risk stratification according to pN classification of AJCC8 staging system performed poorly as a prognostic indicator. BackgroundThe 8th edition American Joint Committee on Cancer staging manual (AJCC8) introduced a separate staging system for head and neck cutaneous squamous cell carcinoma (HNcSCC) which parallels mucosal SCC and incorporates extranodal extension (ENE). This study aims to evaluate its prognostic utility.MethodsUnivariate analysis of 1146 patients with metastatic HNcSCC from four Australian cancer centers was performed according to both AJCC 7th (AJCC7) and the 8th editions.ResultsAJCC8 increased classification of 924 (80.6%) patients to either pN2a or pN3b and 341 patients (29.8%) from stage III to IV compared to AJCC7. The disease‐specific survival (DSS) was not significantly different between pN1, pN2 or pN3a categories per AJCC8. Estimates of model performance for the AJCC8 pN staging revealed modest predictive capacity (Harrell's C of 0.62 for DSS).ConclusionsThe risk stratification according to pN classification of AJCC8 staging system performed poorly as a prognostic indicator. |
Author | Gupta, Ruta Magarey, Matthew Ebrahimi, Ardalan Palme, Carsten E. McDowell, Lachlan Gao, Kan Luk, Peter P. Veness, Michael J. Clark, Jonathan R. |
Author_xml | – sequence: 1 givenname: Peter P. orcidid: 0000-0001-8779-4461 surname: Luk fullname: Luk, Peter P. organization: Royal Prince Alfred Hospital, NSW Health Pathology – sequence: 2 givenname: Ardalan orcidid: 0000-0002-5433-3965 surname: Ebrahimi fullname: Ebrahimi, Ardalan organization: The Canberra Hospital – sequence: 3 givenname: Michael J. surname: Veness fullname: Veness, Michael J. organization: Westmead Hospital – sequence: 4 givenname: Lachlan orcidid: 0000-0002-4268-3079 surname: McDowell fullname: McDowell, Lachlan organization: Peter MacCallum Cancer Centre – sequence: 5 givenname: Matthew surname: Magarey fullname: Magarey, Matthew organization: Peter MacCallum Cancer Centre – sequence: 6 givenname: Kan surname: Gao fullname: Gao, Kan organization: Chris O'Brien Lifehouse – sequence: 7 givenname: Carsten E. surname: Palme fullname: Palme, Carsten E. organization: Chris O'Brien Lifehouse – sequence: 8 givenname: Jonathan R. surname: Clark fullname: Clark, Jonathan R. organization: The University of Sydney – sequence: 9 givenname: Ruta surname: Gupta fullname: Gupta, Ruta email: ruta.gupta@health.nsw.gov.au organization: The University of Sydney |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33118253$$D View this record in MEDLINE/PubMed |
BookMark | eNp1kctu1DAUhi1URC-w4AXQkVixSGvHHifDbjQUCqoEC1hHJ87JjEtiT31pNTsegefhcXgSkk67ZOUjn0_f-aX_lB0574ix14KfC87Liy1156VeiPIZOxF8WRVcquponpUsJK_UMTuN8YZzLrUqX7BjKYWoy4U8YX--Bb9xPiZr4A6HTOB7SFuCOm2BOpusd7AaKViDDr546xKs_TjaGOfNGp2hAM53OEBMuLFuA3EfE43Q-wA7TJZcinBvJ9-WsAN0HTgyP8HkhI58jhBvM47zYGgYwGAw1vkR38MKxjwk-_fXb-umiCnPcR4u5W7_kj3vcYj06vE9Yz8-Xn5fXxXXXz99Xq-uCyPruiyUrtu2EkS1oVIrvpSqrbGsKtJkWtKVQuQKF1XPsROke1H3S6SOkySkRSvP2NuDdxf8baaYmhufwxQjNqWqtFrWWumJenegTPAxBuqbXbAjhn0jeDO31EwtNQ8tTeybR2Nux-n3iXyqZQIuDsC9HWj_f1NzdfnhoPwH0CijVw |
CitedBy_id | crossref_primary_10_1097_MOO_0000000000000772 crossref_primary_10_1186_s12885_024_12384_6 crossref_primary_10_3389_fonc_2024_1399047 crossref_primary_10_1056_NEJMra2206348 crossref_primary_10_3390_cancers14205101 crossref_primary_10_1002_hed_27475 crossref_primary_10_1002_hed_27486 crossref_primary_10_3390_curroncol30070487 crossref_primary_10_3892_mco_2024_2739 |
Cites_doi | 10.1155/2011/502723 10.1002/hed.22941 10.1002/cncr.24208 10.1111/ajd.12282 10.1007/978-3-319-40618-3 10.1002/lary.24549 10.1002/hed.24765 10.1002/cncr.24855 10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4 10.1245/s10434-018-6340-x 10.1002/hed.23096 10.1002/jso.24883 10.1109/TAC.1974.1100705 10.1016/j.bjps.2006.03.043 10.1016/j.hoc.2018.08.001 10.1016/j.ejca.2006.01.062 10.1111/j.1365-2133.2012.10830.x 10.1002/hed.25599 10.1245/s10434-012-2504-2 10.1002/hed.25912 10.1002/(SICI)1097-0258(19961015)15:19<1999::AID-SIM353>3.0.CO;2-D 10.1002/hed.24190 10.1002/hed.23102 10.1002/jso.21092 10.1245/s10434-010-1009-0 10.1002/cncr.21698 10.1002/cncr.28596 |
ContentType | Journal Article |
Copyright | 2020 Wiley Periodicals LLC 2020 Wiley Periodicals LLC. 2021 Wiley Periodicals LLC. |
Copyright_xml | – notice: 2020 Wiley Periodicals LLC – notice: 2020 Wiley Periodicals LLC. – notice: 2021 Wiley Periodicals LLC. |
DBID | NPM AAYXX CITATION 7QP 7TK K9. |
DOI | 10.1002/hed.26512 |
DatabaseName | PubMed CrossRef Calcium & Calcified Tissue Abstracts Neurosciences Abstracts ProQuest Health & Medical Complete (Alumni) |
DatabaseTitle | PubMed CrossRef ProQuest Health & Medical Complete (Alumni) Calcium & Calcified Tissue Abstracts Neurosciences Abstracts |
DatabaseTitleList | PubMed ProQuest Health & Medical Complete (Alumni) |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
EISSN | 1097-0347 |
EndPage | 567 |
ExternalDocumentID | 10_1002_hed_26512 33118253 HED26512 |
Genre | article Journal Article |
GroupedDBID | --- .3N .55 .GA .Y3 05W 0R~ 10A 1L6 1OB 1OC 1ZS 31~ 33P 36B 3O- 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABEML ABIJN ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADZMN ADZOD AEEZP AEIGN AEIMD AEQDE AEUQT AEUYR AFBPY AFFPM AFGKR AFPWT AFZJQ AHBTC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BROTX BRXPI BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DUUFO EBD EBS EJD EMB EMOBN F00 F01 F04 F5P FEDTE G-S G.N GNP GODZA H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KBYEO KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M6P MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO ROL RWI RX1 RYL SAMSI SUPJJ SV3 TEORI UB1 V2E W8V W99 WBKPD WH7 WHWMO WIH WIJ WIK WJL WOHZO WQJ WRC WUP WVDHM WWO WXI WXSBR X7M XG1 XPP XV2 ZGI ZXP ZZTAW ~IA ~WT NPM AAMNL AAYXX ACRPL CITATION 7QP 7TK K9. |
ID | FETCH-LOGICAL-c3882-468bb71ee8ce2640934b8a277e6ecbe674aa04a57f0ad1e6f18f9aed0e3eae5b3 |
IEDL.DBID | DR2 |
ISSN | 1043-3074 |
IngestDate | Thu Oct 10 17:36:07 EDT 2024 Fri Dec 06 07:22:19 EST 2024 Sat Sep 28 08:46:02 EDT 2024 Sat Aug 24 01:07:03 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 2 |
Keywords | head and neck cutaneous squamous cell carcinoma nodal metastases American Joint Committee on Cancer prognosis staging |
Language | English |
License | 2020 Wiley Periodicals LLC. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c3882-468bb71ee8ce2640934b8a277e6ecbe674aa04a57f0ad1e6f18f9aed0e3eae5b3 |
Notes | Peter P. Luk and Ardalan Ebrahimi contributed equally to this study. |
ORCID | 0000-0002-4268-3079 0000-0002-5433-3965 0000-0001-8779-4461 |
OpenAccessLink | http://minerva-access.unimelb.edu.au/bitstreams/9236538d-8a2d-5a44-9902-ad94eb701e68/download |
PMID | 33118253 |
PQID | 2476498646 |
PQPubID | 996355 |
PageCount | 10 |
ParticipantIDs | proquest_journals_2476498646 crossref_primary_10_1002_hed_26512 pubmed_primary_33118253 wiley_primary_10_1002_hed_26512_HED26512 |
PublicationCentury | 2000 |
PublicationDate | February 2021 2021-Feb 2021-02-00 20210201 |
PublicationDateYYYYMMDD | 2021-02-01 |
PublicationDate_xml | – month: 02 year: 2021 text: February 2021 |
PublicationDecade | 2020 |
PublicationPlace | Hoboken, USA |
PublicationPlace_xml | – name: Hoboken, USA – name: United States – name: Houston |
PublicationTitle | Head & neck |
PublicationTitleAlternate | Head Neck |
PublicationYear | 2021 |
Publisher | John Wiley & Sons, Inc Wiley Subscription Services, Inc |
Publisher_xml | – name: John Wiley & Sons, Inc – name: Wiley Subscription Services, Inc |
References | 2015; 56 2012; 166 2019; 33 2010 2010; 17 2006; 59 2012; 19 2008; 98 2016; 38 1996; 15 1974; 19 2009; 115 2018; 25 2011; 2011 2006; 42 2018; 117 2019; 41 2017; 39 2013; 35 2010; 116 2017 2014; 120 2006; 106 2012; 9 2014; 124 e_1_2_7_5_1 e_1_2_7_4_1 e_1_2_7_3_1 Edge S (e_1_2_7_6_1) 2010 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_19_1 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_16_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_11_1 e_1_2_7_10_1 e_1_2_7_26_1 e_1_2_7_27_1 e_1_2_7_28_1 e_1_2_7_29_1 e_1_2_7_30_1 e_1_2_7_25_1 e_1_2_7_24_1 e_1_2_7_23_1 e_1_2_7_22_1 e_1_2_7_21_1 e_1_2_7_20_1 Noguti J (e_1_2_7_12_1) 2012; 9 Amin ME (e_1_2_7_7_1) 2017 |
References_xml | – volume: 124 start-page: 1598 year: 2014 end-page: 1602 article-title: Comparison of the AJCC N staging system in mucosal and cutaneous squamous head and neck cancer publication-title: Laryngoscope – volume: 38 start-page: E1192 year: 2016 end-page: E1199 article-title: Influence of extracapsular nodal spread extent on prognosis of oral squamous cell carcinoma publication-title: Head Neck – start-page: 672 year: 2010 – volume: 98 start-page: 101 year: 2008 end-page: 105 article-title: Parotid and cervical nodal status predict prognosis for patients with head and neck metastatic cutaneous squamous cell carcinoma publication-title: J Surg Oncol – volume: 116 start-page: 1298 year: 2010 end-page: 1304 article-title: N1S3: a revised staging system for head and neck cutaneous squamous cell carcinoma with lymph node metastases: results of 2 Australian cancer centers publication-title: Cancer – volume: 19 start-page: 4252 year: 2012 end-page: 4258 article-title: Analysis and comparison of the 7th edition American Joint Committee on Cancer (AJCC) nodal staging system for metastatic cutaneous squamous cell carcinoma of the head and neck publication-title: Ann Surg Oncol – volume: 15 start-page: 361 year: 1996 end-page: 387 article-title: Multivariable prognostic models: issues in developing models, evaluating assumptions and adequacy, and measuring and reducing errors publication-title: Stat Med – volume: 59 start-page: 1288 year: 2006 end-page: 1293 article-title: Parotid metastasis—an independent prognostic factor for head and neck cutaneous squamous cell carcinoma publication-title: J Plast Reconstr Aesthet Surg – volume: 41 start-page: 3826 year: 2019 end-page: 3832 article-title: Positive survival trend in metastatic head and neck cutaneous squamous cell carcinoma over four‐decades: multicenter study publication-title: Head Neck – start-page: 1024 year: 2017 – volume: 35 start-page: 1144 year: 2013 end-page: 1148 article-title: Concurrent primary and metastatic cutaneous head and neck squamous cell carcinoma: analysis of prognostic factors publication-title: Head Neck – volume: 120 start-page: 1499 year: 2014 end-page: 1506 article-title: Extent of pathologic extracapsular extension and outcomes in patients with nonoropharyngeal head and neck cancer treated with initial surgical resection publication-title: Cancer – volume: 56 start-page: 258 year: 2015 end-page: 267 article-title: Incidence and prevalence of non‐melanoma skin cancer in Australia: a systematic review publication-title: Australas J Dermatol – volume: 35 start-page: 1138 year: 2013 end-page: 1143 article-title: Prognostic significance of disease‐free interval in head and neck cutaneous squamous cell carcinoma with nodal metastases publication-title: Head Neck – volume: 41 start-page: 1591 year: 2019 end-page: 1596 article-title: A critical analysis of the prognostic performance of the 8th edition American Joint Committee on Cancer staging for metastatic cutaneous squamous cell carcinoma of the head and neck publication-title: Head Neck – volume: 15 start-page: 1999 year: 1996 end-page: 2012 article-title: Explained variation in survival analysis publication-title: Stat Med – volume: 42 start-page: 1863 year: 2006 end-page: 1868 article-title: Meta‐analysis of the prognostic significance of perinodal spread in head and neck squamous cell carcinomas (HNSCC) patients publication-title: Eur J Cancer – volume: 2011 year: 2011 article-title: Cutaneous squamous cell carcinoma of the head and neck publication-title: J Skin Cancer – volume: 25 start-page: 1730 year: 2018 end-page: 1736 article-title: Analysis and comparison of the 8th edition American Joint Committee on Cancer (AJCC) nodal staging system in cutaneous and Oral squamous cell cancer of the head and neck publication-title: Ann Surg Oncol – volume: 9 start-page: 329 year: 2012 end-page: 335 article-title: Metastasis from oral cancer: an overview publication-title: Cancer Genomics Proteomics – volume: 106 start-page: 1078 year: 2006 end-page: 1083 article-title: Implications for clinical staging of metastatic cutaneous squamous carcinoma of the head and neck based on a multicenter study of treatment outcomes publication-title: Cancer – volume: 19 start-page: 716 year: 1974 end-page: 723 article-title: A new look at the statistical model identification publication-title: IEEE Trans Autom Control – volume: 33 start-page: 1 year: 2019 end-page: 12 article-title: Cutaneous squamous cell carcinoma publication-title: Hematol Oncol Clin North Am – volume: 35 start-page: 190 year: 2013 end-page: 194 article-title: Relevance of the primary lesion in the prognosis of metastatic cutaneous squamous cell carcinoma publication-title: Head Neck – volume: 115 start-page: 1883 year: 2009 end-page: 1891 article-title: Metastatic cutaneous squamous cell carcinoma of the head and neck: the immunosuppression, treatment, extranodal spread, and margin status (ITEM) prognostic score to predict outcome and the need to improve survival publication-title: Cancer – volume: 17 start-page: 1979 year: 2010 end-page: 1980 article-title: Improvements in the staging of cutaneous squamous‐cell carcinoma in the 7th edition of the AJCC cancer staging manual publication-title: Ann Surg Oncol – volume: 117 start-page: 765 year: 2018 end-page: 772 article-title: Predictive value of the 8th edition American Joint Commission Cancer (AJCC) nodal staging system for patients with cutaneous squamous cell carcinoma of the head and neck publication-title: J Surg Oncol – volume: 39 start-page: 1462 year: 2017 end-page: 1469 article-title: Reviewing the genetic alterations in high‐risk cutaneous squamous cell carcinoma: a search for prognostic markers and therapeutic targets publication-title: Head Neck – volume: 166 start-page: 1069 year: 2012 end-page: 1080 article-title: A systematic review of worldwide incidence of nonmelanoma skin cancer publication-title: Br J Dermatol – ident: e_1_2_7_4_1 doi: 10.1155/2011/502723 – ident: e_1_2_7_9_1 doi: 10.1002/hed.22941 – ident: e_1_2_7_21_1 doi: 10.1002/cncr.24208 – ident: e_1_2_7_5_1 doi: 10.1111/ajd.12282 – start-page: 1024 volume-title: AJCC Cancer Staging Manual year: 2017 ident: e_1_2_7_7_1 doi: 10.1007/978-3-319-40618-3 contributor: fullname: Amin ME – ident: e_1_2_7_13_1 doi: 10.1002/lary.24549 – ident: e_1_2_7_8_1 doi: 10.1002/hed.24765 – ident: e_1_2_7_20_1 doi: 10.1002/cncr.24855 – ident: e_1_2_7_18_1 doi: 10.1002/(SICI)1097-0258(19960229)15:4<361::AID-SIM168>3.0.CO;2-4 – start-page: 672 volume-title: AJCC Cancer Staging Manual year: 2010 ident: e_1_2_7_6_1 contributor: fullname: Edge S – ident: e_1_2_7_29_1 doi: 10.1245/s10434-018-6340-x – ident: e_1_2_7_10_1 doi: 10.1002/hed.23096 – ident: e_1_2_7_15_1 doi: 10.1002/jso.24883 – ident: e_1_2_7_19_1 doi: 10.1109/TAC.1974.1100705 – ident: e_1_2_7_28_1 doi: 10.1016/j.bjps.2006.03.043 – ident: e_1_2_7_3_1 doi: 10.1016/j.hoc.2018.08.001 – ident: e_1_2_7_23_1 doi: 10.1016/j.ejca.2006.01.062 – ident: e_1_2_7_2_1 doi: 10.1111/j.1365-2133.2012.10830.x – volume: 9 start-page: 329 year: 2012 ident: e_1_2_7_12_1 article-title: Metastasis from oral cancer: an overview publication-title: Cancer Genomics Proteomics contributor: fullname: Noguti J – ident: e_1_2_7_16_1 doi: 10.1002/hed.25599 – ident: e_1_2_7_14_1 doi: 10.1245/s10434-012-2504-2 – ident: e_1_2_7_30_1 doi: 10.1002/hed.25912 – ident: e_1_2_7_17_1 doi: 10.1002/(SICI)1097-0258(19961015)15:19<1999::AID-SIM353>3.0.CO;2-D – ident: e_1_2_7_24_1 doi: 10.1002/hed.24190 – ident: e_1_2_7_11_1 doi: 10.1002/hed.23102 – ident: e_1_2_7_27_1 doi: 10.1002/jso.21092 – ident: e_1_2_7_26_1 doi: 10.1245/s10434-010-1009-0 – ident: e_1_2_7_25_1 doi: 10.1002/cncr.21698 – ident: e_1_2_7_22_1 doi: 10.1002/cncr.28596 |
SSID | ssj0003642 |
Score | 2.4284208 |
Snippet | Background
The 8th edition American Joint Committee on Cancer staging manual (AJCC8) introduced a separate staging system for head and neck cutaneous squamous... The 8th edition American Joint Committee on Cancer staging manual (AJCC8) introduced a separate staging system for head and neck cutaneous squamous cell... BackgroundThe 8th edition American Joint Committee on Cancer staging manual (AJCC8) introduced a separate staging system for head and neck cutaneous squamous... |
SourceID | proquest crossref pubmed wiley |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 558 |
SubjectTerms | American Joint Committee on Cancer Cancer Head and neck head and neck cutaneous squamous cell carcinoma Metastases Mucosa nodal metastases prognosis Skin cancer Squamous cell carcinoma staging |
Title | Prognostic value of the 8th edition American Joint Commission Cancer nodal staging system for patients with head and neck cutaneous squamous cell carcinoma: A multi‐institutional study |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhed.26512 https://www.ncbi.nlm.nih.gov/pubmed/33118253 https://www.proquest.com/docview/2476498646 |
Volume | 43 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Li9RAEG6WPXnxga_RVQrx4CWzme5Od0ZPyz4YFhQRF_YghH5U2GHZjk6Siyd_gr_Hn-MvsauTzLKKIF5CCEmRdFenvq7--ivGXkpunLamzmrNTSal59lSFvFQxtlEjC_aO9qc_PadWp3J0_PifIe9mfbCDPoQ24QbjYz0v6YBbmy7fy0aeoF-zlWRKgwvhCY639GHa-kooeSw0ikF5VfkpCqU8_3tkzdj0R8A8yZeTQHn5A77NL3qwDO5nPednbuvv6k4_ue33GW3RyAKB4Pn3GM7GO6zH-83DTHv4jUgGXCEpoYIEaHsLiCGOepFmBZ54LRZhw5oi8mauLQBDsmFNhAaHy1H2EkFkGDQioYIjmEUcW2Bsr8Qw4AHEzwEdJfg-ghTselbaL_0hhISQIsK4KjYUWiuzGs4gER__Pnt-3qkOKQ8JiSJ3Afs7OT44-EqG6s7ZE4QrJeqtFYvEEuHEZXlSyFtabjWqNBZVFoak0tT6Do3foGqXpT10qDPUaDBwoqHbDc0AR8z4A59yZ0V8WcjMRdGWcqRahfnnhjtzNiLqZ-rz4OIRzXINfMqNn2Vmn7G9iYPqMZx3FZcaiVJwV7N2KPBK7YWhKDJWSFm7FXq27-brlbHR-nkyb_f-pTd4kSfSQTxPbbbbXp8FvFPZ58nR_8FJgcFmw |
link.rule.ids | 314,780,784,1375,27924,27925,46294,46718 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELaqcoALD_FaWmCEOHDJNms7dhZxqfrQUtoKoVbqBUV-TNRV1QR2k0tP_AR-Dz-HX4LHSbYqCAlxiaIosRJ7JvN5_Pkbxl5Lbpy2pkxKzU0ipefJVGbhkIfZRIgv2jvanHx0rGan8uAsO1tj74a9MJ0-xCrhRp4R_9fk4JSQ3rpWDT1HP-YqoxLDt4K7T4jQtfvpWjxKKNmtdUpBGRY56AqlfGv16M1o9AfEvIlYY8jZv8c-Dy_bMU0uxm1jx-7qNx3H__2a--xuj0VhuzOeB2wNq4fsx8dFTeS7cA1ICRyhLiGgRMibcwiRjgYShnUeOKjnVQO0y2ROdNoKdsiKFlDVPrQckCfVQIJOLhoCPoZex3UJlACGEAk8mMpDhe4CXBuQKtbtEpZfW0M5CaB1BXBU76iqL81b2IbIgPz57fu8ZznEVCZEldxH7HR_72RnlvQFHhInCNlLlVurJ4i5wwDM0qmQNjdca1ToLCotjUmlyXSZGj9BVU7ycmrQpyjQYGbFY7Ze1RU-ZcAd-pw7K8L_RmIqjLKUJtUuTD8xtDNir4aBLr50Oh5Fp9jMi9D1Rez6EdscTKDoXXlZcKmVJBF7NWJPOrNYtSAEzc8yMWJv4uD-velitrcbT579-60v2e3ZydFhcfj--MMGu8OJTRP54ptsvVm0-DzAoca-iFb_C3JrCbw |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NbtQwELaqIiEu_Ii_hQIjxIFLtlnbsbNwqrpdLQWqClGpB6TIPxN1VZGU3eTCiUfgeXgcngSPk2xVEBLiEkVRMkrscebz-PM3jL2Q3DhtTZmUmptESs-TqczCIQ-ziRBftHe0Ofn9kVqcyMPT7HSLvR72wnT6EJuEG42M-L-mAX7hy91L0dAz9GOuMqowfE0qPiXh_NmHS-0ooWS31CkFJVjkICuU8t3No1eD0R8I8ypgjRFnfot9Gt61I5qcj9vGjt3X32Qc__NjbrObPRKFvc517rAtrO6yH8ermqh34RqQDjhCXULAiJA3ZxDiHHUjDKs8cFgvqwZoj8mSyLQV7JMPraCqfbAccCdVQIJOLBoCOoZexXUNlP6FEAc8mMpDhe4cXBtwKtbtGtZfWkMZCaBVBXBU7aiqP5tXsAeR__jz2_dlz3GIiUyIGrn32Mn84OP-IunLOyROEK6XKrdWTxBzhwGWpVMhbW641qjQWVRaGpNKk-kyNX6Cqpzk5dSgT1GgwcyK-2y7qit8yIA79Dl3VoS_jcRUGGUpSapdmHxisDNiz4d-Li46FY-i02vmRWj6Ijb9iO0MHlD0A3ldcKmVJAl7NWIPOq_YWBCCZmeZGLGXsW__brpYHMziyaN_v_UZu348mxfv3hy9fcxucKLSRLL4DttuVi0-CViosU-jz_8CYMwIaw |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prognostic+value+of+the+8th+edition+American+Joint+Commission+Cancer+nodal+staging+system+for+patients+with+head+and+neck+cutaneous+squamous+cell+carcinoma%3A+A+multi%E2%80%90institutional+study&rft.jtitle=Head+%26+neck&rft.au=Luk%2C+Peter+P.&rft.au=Ebrahimi%2C+Ardalan&rft.au=Veness%2C+Michael+J.&rft.au=McDowell%2C+Lachlan&rft.date=2021-02-01&rft.issn=1043-3074&rft.eissn=1097-0347&rft.volume=43&rft.issue=2&rft.spage=558&rft.epage=567&rft_id=info:doi/10.1002%2Fhed.26512&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_hed_26512 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1043-3074&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1043-3074&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1043-3074&client=summon |