Neurophysiological effects of multiple mood episodes in bipolar disorder

• Published in: Bipolar disorders Vol. 21; no. 6; pp. 503 - 513
• Main Authors: Borgelt, Logan, Strakowski, Stephen M., DelBello, Melissa P., Weber, Wade, Eliassen, James C., Komoroski, Richard A., Chu, Wen‐Jang, Welge, Jeffrey A., Blom, Thomas J., Rummelhoff, Emily, Tallman, Maxwell, Lee, Jing‐Huei, Adler, Caleb M.
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.09.2019
• Subjects: Adult; Affect - physiology; Amygdala; Amygdala - physiopathology; Aspartic Acid - analogs & derivatives; Aspartic Acid - metabolism; Attention - physiology; Bipolar disorder; Bipolar Disorder - diagnostic imaging; Bipolar Disorder - physiopathology; Bipolar Disorder - psychology; Brain - diagnostic imaging; Brain - physiopathology; Brain Mapping; Brodmann's area; Cerebral Cortex - physiopathology; Corpus Striatum - physiopathology; Cortex (cingulate); Emotions; Emotions - physiology; Female; fMRI; Functional magnetic resonance imaging; Gyrus Cinguli - metabolism; Gyrus Cinguli - physiopathology; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; mania; Mood; MRS; Neostriatum; Neuroimaging; neuroprogression; Neuropsychological Tests; Prefrontal cortex; Prefrontal Cortex - physiopathology; Putamen; Thalamus; Thalamus - physiopathology; fMRI; bipolar disorder; neuroprogression; MRS; mania

Objectives Bipolar disorder is marked by progressive symptomatic changes, which have been linked with episode‐related structural findings—particularly in the prefrontal cortex. However, few studies have examined neurofunctional and neurochemical effects of disease burden. In this study, we compared...