Risk factors affecting outcome of unrelated cord blood transplantation for children with familial haemophagocytic lymphohistiocytosis

• Published in: British journal of haematology Vol. 184; no. 3; pp. 397 - 404
• Main Authors: Furtado‐Silva, Juliana Montibeller, Paviglianiti, Annalisa, Ruggeri, Annalisa, Boelens, Jaap Jan, Veys, Paul, Ahmari, Ali Abdallah, Zecca, Marco, Locatelli, Franco, Michel, Gerard, Volt, Fernanda, Kenzey, Chantal, Sedlacek, Petr, Rao, Kanchan, Lankester, Arjan, Gluckman, Eliane, Rocha, Vanderson
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.02.2019
• Subjects: Bone marrow; Bone marrow transplantation; Busulfan; Children; Cord blood; Familial haemophagocytic lymphohistiocytosis; Globulins; Graft-versus-host reaction; Hematology; Hematopoietic stem cells; Histocompatibility antigen HLA; Incidence; Monoclonal antibodies; Multivariate analysis; Paediatric; Peripheral blood; Risk factors; Stem cell transplantation; Stem cells; transplant outcomes; Transplantation; Umbilical cord; Umbilical cord blood transplantation; unrelated donor; Paediatric; unrelated donor; Familial haemophagocytic lymphohistiocytosis; transplant outcomes; Umbilical cord blood transplantation

Summary Allogeneic haematopoietic stem cell transplantation is still the only available curative option for Familial Haemophagocytic Lymphohistiocytosis (FHLH). Most studies report outcomes after bone marrow or peripheral blood stem cell transplantation. We analysed the outcomes of 118 children with...