Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/β‐catenin pathway

• Published in: Journal of bone and mineral research Vol. 36; no. 8; pp. 1605 - 1620
• Main Authors: Yang, Yu‐ying, Zhou, Yan‐man, Xu, Jing‐zun, Sun, Li‐hao, Tao, Bei, Wang, Wei‐qing, Wang, Ji‐qiu, Zhao, Hong‐yan, Liu, Jian‐min
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2021; Oxford University Press
• Subjects: Animals; beta Catenin - metabolism; Bone growth; Bone mass; BONE REMODELING; Catenin; Cell Differentiation; Energy metabolism; GLYCOLYSIS; Lactic acid; Lgr4; Metabolism; Mice; Osteoblastogenesis; OSTEOBLASTS; Osteoblasts - metabolism; Osteogenesis; OSTEOPOROSIS; Pyruvic acid; Receptors, G-Protein-Coupled - genetics; Tumorigenesis; Wnt protein; Wnt Signaling Pathway; GLYCOLYSIS; Lgr4; BONE REMODELING; OSTEOPOROSIS; OSTEOBLASTS

ABSTRACT Lgr4, a G‐protein‐coupled receptor, is associated with various physiological and pathological processes including oncogenesis, energy metabolism, and bone remodeling. However, whether Lgr4 is involved in osteoblasts' metabolism is not clear. Here we uncover that in preosteoblast cell l...