Antimicrobial Photodynamic Inactivation Using Topical and Superhydrophobic Sensitizer Techniques: A Perspective from Diffusion in Biofilms

• Published in: Photochemistry and photobiology Vol. 97; no. 6; pp. 1266 - 1277
• Main Authors: Tonon, Caroline Coradi, Ashraf, Shoaib, Alburquerque, José Quílez, Souza Rastelli, Alessandra Nara, Hasan, Tayyaba, Lyons, Alan M., Greer, Alexander
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.11.2021
• Subjects: Anti-Bacterial Agents - therapeutic use; Anti-Infective Agents - pharmacology; Antiinfectives and antibacterials; Antimicrobial agents; Biofilms; Deactivation; Diffusion; Hydrophobic and Hydrophilic Interactions; Hydrophobic surfaces; Hydrophobicity; Inactivation; Molecular diffusion; Nanoparticles; Photoactivation; Photochemotherapy; Photosensitizing Agents - pharmacology; Photosensitizing Agents - therapeutic use; Reactive Oxygen Species

This review describes nanoparticle and dye diffusion in bacterial biofilms in the context of antimicrobial photodynamic inactivation (aPDI). aPDI requires the diffusion of a photosensitizer (Sens) into the biofilm and subsequent photoactivation of oxygen for the generation of reactive oxygen species...