Antimicrobial Photodynamic Inactivation Using Topical and Superhydrophobic Sensitizer Techniques: A Perspective from Diffusion in Biofilms

This review describes nanoparticle and dye diffusion in bacterial biofilms in the context of antimicrobial photodynamic inactivation (aPDI). aPDI requires the diffusion of a photosensitizer (Sens) into the biofilm and subsequent photoactivation of oxygen for the generation of reactive oxygen species...

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Published inPhotochemistry and photobiology Vol. 97; no. 6; pp. 1266 - 1277
Main Authors Tonon, Caroline Coradi, Ashraf, Shoaib, Alburquerque, José Quílez, Souza Rastelli, Alessandra Nara, Hasan, Tayyaba, Lyons, Alan M., Greer, Alexander
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.11.2021
Subjects
Anti-Bacterial Agents - therapeutic use
Anti-Infective Agents - pharmacology
Antiinfectives and antibacterials
Antimicrobial agents
Biofilms
Deactivation
Diffusion
Hydrophobic and Hydrophilic Interactions
Hydrophobic surfaces
Hydrophobicity
Inactivation
Molecular diffusion
Nanoparticles
Photoactivation
Photochemotherapy
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
Reactive Oxygen Species
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Abstract This review describes nanoparticle and dye diffusion in bacterial biofilms in the context of antimicrobial photodynamic inactivation (aPDI). aPDI requires the diffusion of a photosensitizer (Sens) into the biofilm and subsequent photoactivation of oxygen for the generation of reactive oxygen species (ROS) that inactivate microbes. Molecular diffusion in biofilms has been long investigated, whereas this review is intended to draw a logical link between diffusion in biofilms and ROS, a combination that leads to the current state of aPDI and superhydrophobic aPDI (SH‐aPDI). This review should be of interest to photochemists, photobiologists and researchers in material and antimicrobial sciences as is ties together conventional aPDI with the emerging subject of SH‐aPDI. There is interest in photodynamic inactivation (aPDI), but it requires the diffusion of sensitizer into the biofilm. Several factors can affect the diffusion, including biofilm complexity, zeta potential, formal charge, and particle size. Superhydrophobic antimicrobial photodynamic inactivation (SH‐aPDI) is a promising method to inactivate biofilms due to its ability to deliver airborne singlet oxygen (1O2). Airborne 1O2 delivery via SH‐aPDI obviates the need for sensitizer penetration into the biofilm as opposed to aPDI which depends on topically applied sensitizer.
AbstractList This review describes nanoparticle and dye diffusion in bacterial biofilms in the context of antimicrobial photodynamic inactivation (aPDI). aPDI requires the diffusion of a photosensitizer (Sens) into the biofilm and subsequent photoactivation of oxygen for the generation of reactive oxygen species (ROS) that inactivate microbes. Molecular diffusion in biofilms has been long investigated, whereas this review is intended to draw a logical link between diffusion in biofilms and ROS, a combination that leads to the current state of aPDI and superhydrophobic aPDI (SH-aPDI). This review should be of interest to photochemists, photobiologists and researchers in material and antimicrobial sciences as is ties together conventional aPDI with the emerging subject of SH-aPDI.
This review describes nanoparticle and dye diffusion in bacterial biofilms in the context of antimicrobial photodynamic inactivation (aPDI). aPDI requires the diffusion of a photosensitizer (Sens) into the biofilm and subsequent photoactivation of oxygen for the generation of reactive oxygen species (ROS) that inactivate microbes. Molecular diffusion in biofilms has been long investigated, whereas this review is intended to draw a logical link between diffusion in biofilms and ROS, a combination that leads to the current state of aPDI and superhydrophobic aPDI (SH-aPDI). This review should be of interest to photochemists, photobiologists and researchers in material and antimicrobial sciences as is ties together conventional aPDI with the emerging subject of SH-aPDI.This review describes nanoparticle and dye diffusion in bacterial biofilms in the context of antimicrobial photodynamic inactivation (aPDI). aPDI requires the diffusion of a photosensitizer (Sens) into the biofilm and subsequent photoactivation of oxygen for the generation of reactive oxygen species (ROS) that inactivate microbes. Molecular diffusion in biofilms has been long investigated, whereas this review is intended to draw a logical link between diffusion in biofilms and ROS, a combination that leads to the current state of aPDI and superhydrophobic aPDI (SH-aPDI). This review should be of interest to photochemists, photobiologists and researchers in material and antimicrobial sciences as is ties together conventional aPDI with the emerging subject of SH-aPDI.
This review describes nanoparticle and dye diffusion in bacterial biofilms in the context of antimicrobial photodynamic inactivation (aPDI). aPDI requires the diffusion of a photosensitizer (Sens) into the biofilm and subsequent photoactivation of oxygen for the generation of reactive oxygen species (ROS) that inactivate microbes. Molecular diffusion in biofilms has been long investigated, whereas this review is intended to draw a logical link between diffusion in biofilms and ROS, a combination that leads to the current state of aPDI and superhydrophobic aPDI (SH‐aPDI). This review should be of interest to photochemists, photobiologists and researchers in material and antimicrobial sciences as is ties together conventional aPDI with the emerging subject of SH‐aPDI. There is interest in photodynamic inactivation (aPDI), but it requires the diffusion of sensitizer into the biofilm. Several factors can affect the diffusion, including biofilm complexity, zeta potential, formal charge, and particle size. Superhydrophobic antimicrobial photodynamic inactivation (SH‐aPDI) is a promising method to inactivate biofilms due to its ability to deliver airborne singlet oxygen (1O2). Airborne 1O2 delivery via SH‐aPDI obviates the need for sensitizer penetration into the biofilm as opposed to aPDI which depends on topically applied sensitizer.
Author Greer, Alexander
Ashraf, Shoaib
Alburquerque, José Quílez
Souza Rastelli, Alessandra Nara
Tonon, Caroline Coradi
Hasan, Tayyaba
Lyons, Alan M.
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This article is part of a Special Issue celebrating the career of Dr. Edward Clennan
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Snippet This review describes nanoparticle and dye diffusion in bacterial biofilms in the context of antimicrobial photodynamic inactivation (aPDI). aPDI requires the...
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SubjectTerms Anti-Bacterial Agents - therapeutic use
Anti-Infective Agents - pharmacology
Antiinfectives and antibacterials
Antimicrobial agents
Biofilms
Deactivation
Diffusion
Hydrophobic and Hydrophilic Interactions
Hydrophobic surfaces
Hydrophobicity
Inactivation
Molecular diffusion
Nanoparticles
Photoactivation
Photochemotherapy
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
Reactive Oxygen Species
Title Antimicrobial Photodynamic Inactivation Using Topical and Superhydrophobic Sensitizer Techniques: A Perspective from Diffusion in Biofilms
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https://www.ncbi.nlm.nih.gov/pubmed/34097752
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