Ferroptosis and central nervous system demyelinating diseases

• Published in: Journal of neurochemistry Vol. 165; no. 6; pp. 759 - 771
• Main Authors: Qin, Danqing, Li, Dong, Wang, Chunjuan, Guo, Shougang
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.06.2023
• Subjects: Apoptosis; Autophagy; Cell death; Central Nervous System; Central Nervous System Diseases; Demyelinating diseases; Demyelination; Encephalomyelitis; Ferroptosis; Glutathione; Humans; Iron; iron balance disorder; Iron Overload; Lipid peroxidation; Lipids; Metabolic pathways; Multiple Sclerosis; Necrosis; Neuromyelitis; Neuromyelitis Optica; Oxidative stress; Pathogenesis; Peroxidation; Therapeutic targets; iron overload; cell death; demyelinating diseases; iron balance disorder; multiple sclerosis; oxidative stress

Ferroptosis is a newly discovered programmed cell death caused by intracellular iron excess and glutathione (GSH) system imbalance, resulting in fatal lipid peroxidation. It is different from necrosis, apoptosis, autophagy, and other forms of cell death. Accumulating evidences suggest that brain iro...