Comparison of the metabolomic profiles of irritable bowel syndrome patients with ulcerative colitis patients and healthy controls: new insights into pathophysiology and potential biomarkers

• Published in: Alimentary pharmacology & therapeutics Vol. 49; no. 6; pp. 723 - 732
• Main Authors: Keshteli, Ammar Hassanzadeh, Madsen, Karen L., Mandal, Rupasri, Boeckxstaens, Guy E., Bercik, Premysl, De Palma, Giada, Reed, David E., Wishart, David, Vanner, Stephen, Dieleman, Levinus A.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.03.2019
• Subjects: Adult; Aged; Biomarkers; Biomarkers - metabolism; Choline; Chromatography; Cohort Studies; Colitis, Ulcerative - diagnosis; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - physiopathology; Colon; Cross-Sectional Studies; Dopamine; Female; Gas Chromatography-Mass Spectrometry - methods; Histamine; Humans; Inflammatory bowel disease; Intestine; Irritable bowel syndrome; Irritable Bowel Syndrome - diagnosis; Irritable Bowel Syndrome - metabolism; Irritable Bowel Syndrome - physiopathology; Liquid chromatography; Male; Mass spectrometry; Mass spectroscopy; Metabolites; Metabolome - physiology; Metabolomics; Metabolomics - methods; Middle Aged; Organic acids; p-Hydroxybenzoic acid; Remission; Scientific imaging; Ulcerative colitis; Urine

Summary Background Evaluation of the metabolomic profile of patients with irritable bowel syndrome offers an opportunity to identify novel pathophysiological targets and biomarkers that could discriminate this disorder from related conditions. Aim To identify potential urinary biomarkers that discri...