Contemplating IL‐6, a double‐edged sword cytokine: Which side to use for stroke pathology?

• Published in: CNS neuroscience & therapeutics Vol. 29; no. 2; pp. 493 - 497
• Main Authors: Monsour, Molly, Croci, Davide M., Agazzi, Siviero, Borlongan, Cesar V.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2023
• Subjects: Aneurysms; Angiogenesis; Antagonists; Anti-Inflammatory Agents; Apoptosis; Biomarkers; Bone marrow; Brain research; Cytokine Receptor gp130 - metabolism; Cytokines; hemorrhagic stroke; Humans; Inflammation; Interleukin 6; Interleukin-6 - metabolism; Ischemia; ischemic stroke; Medical prognosis; Neurogenesis; Pathology; Signal transduction; signaling; Stem cells; Stroke; interleukin 6; hemorrhagic stroke; signaling; ischemic stroke

Interleukin (IL)‐6 is a unique cytokine due to its dual signaling, with one pathway being pro‐inflammatory (trans) and the other homeostatic (classical). Both of these pathways have been implicated in neuroinflammation following stroke, with initial inflammatory mechanisms being protective and later...