Two transcription factors cooperatively regulate DHN melanin biosynthesis and development in Pestalotiopsis fici

• Published in: Molecular microbiology Vol. 112; no. 2; pp. 649 - 666
• Main Authors: Zhang, Peng, Zhou, Shuang, Wang, Gang, An, Zhiqiang, Liu, Xingzhong, Li, Kuan, Yin, Wen‐Bing
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.08.2019
• Subjects: Biosynthesis; Biosynthetic Pathways; Cell walls; Clonal deletion; Conidia; CRISPR; Dehydration; Disruption; Fungal Proteins - genetics; Fungal Proteins - metabolism; Fungi; Gene deletion; Gene expression; Gene Expression Regulation, Developmental; Gene Expression Regulation, Fungal; Hyphae; Integrity; Melanin; Melanins - biosynthesis; Naphthols; Oxidative stress; Pathogenesis; Pestalotiopsis; Proleptacis fici; Regulatory mechanisms (biology); Scytalone dehydratase; Spores, Fungal - genetics; Spores, Fungal - metabolism; Transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; Xylariales - genetics; Xylariales - growth & development; Xylariales - metabolism

Summary Fungal 1,8‐dihydroxynaphthalene (DHN) melanin plays important roles in UV protection, oxidative stress and pathogenesis. However, knowledge of the regulatory mechanisms of its biosynthesis is limited. Previous studies showed two transcription factors, PfmaF and PfmaH, located in the DHN mela...