Effects of autologous platelet transfusion on platelet inhibition in ticagrelor‐treated and clopidogrel‐treated subjects

• Published in: Journal of thrombosis and haemostasis Vol. 14; no. 12; pp. 2342 - 2352
• Main Authors: Teng, R., Carlson, G. F., Nylander, S., Andersson, T. L. G.
• Format: Journal Article
• Language: English
• Published: England Elsevier Limited 01.12.2016
• Subjects: Adenosine - analogs & derivatives; Adenosine - pharmacology; Adult; antiplatelet agents; Blood Component Removal; Blood Platelets - cytology; Blood Platelets - drug effects; Body Mass Index; Case-Control Studies; clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19 - genetics; Female; Hemostasis; Humans; Male; platelet aggregation; Platelet Aggregation Inhibitors - pharmacology; platelet transfusion; Platelet Transfusion - methods; Purinergic P2Y Receptor Antagonists - pharmacology; Reproducibility of Results; ticagrelor; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacology; Time Factors; Young Adult; clopidogrel; antiplatelet agents; ticagrelor; platelet transfusion; platelet aggregation

Essentials Limited data on hemostatic benefits of platelet transfusion (PT) exist. 44 healthy subjects had a single dose of ticagrelor or clopidogrel ± autologous PT post‐dosing. PT did not reverse ticagrelor's antiplatelet effects and had minimal impact post clopidogrel. Post‐ticagrelor, PT is...