Structural network topology in limbic encephalitis is associated with amygdala enlargement, memory performance and serostatus

• Published in: Epilepsia (Copenhagen) Vol. 61; no. 10; pp. e140 - e145
• Main Authors: Bauer, Tobias, David, Bastian, Ernst, Leon, Becker, Albert J., Witt, Juri‐Alexander, Helmstaedter, Christoph, Wagner, Jan, Weber, Bernd, Elger, Christian E., Surges, Rainer, Rüber, Theodor
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.10.2020
• Subjects: Adult; Aged; Amygdala; Amygdala - diagnostic imaging; Autoantibodies; Autoantibodies - blood; Autoimmune diseases; Biomarkers - blood; brain graph; Cohort Studies; Contactin; Encephalitis; Epilepsy; Epilepsy - blood; Epilepsy - diagnostic imaging; Female; Glioma; Glutamate decarboxylase; Glutamate Decarboxylase - blood; Glutamic acid; Hippocampus; Humans; Hypertrophy; Intracellular Signaling Peptides and Proteins - blood; Leucine; limbic encephalitis; Limbic Encephalitis - blood; Limbic Encephalitis - diagnostic imaging; Magnetic resonance imaging; Male; Memory Disorders - blood; Memory Disorders - diagnostic imaging; Middle Aged; Nerve Net - diagnostic imaging; Neural networks; Neuroimaging; Sclerosis; structural connectivity; Temporal lobe; temporal lobe epilepsy; structural connectivity; temporal lobe epilepsy; limbic encephalitis; brain graph
• ISSN: 0013-9580; 1528-1167; 1528-1167
• DOI: 10.1111/epi.16691

Limbic encephalitis (LE) forms a spectrum of autoimmune diseases involving temporal lobe epilepsy and memory impairment. Imaging features of LE are known to depend on the associated antibody and to occur on the brain network level. However, first studies investigating brain networks in LE have eithe...