Vaccine potential of HLA‐A2 epitopes from Leishmania Cysteine Protease Type III (CPC)

• Published in: Parasite immunology Vol. 39; no. 9
• Main Authors: Dikhit, M. R., Amit, A., Singh, A. K., Kumar, A., Mansuri, R., Sinha, S., Topno, R. K., Mishra, R., Das, V. N. R., Pandey, K., Sahoo, G. C., Ali, V., Bimal, S., Das, P.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2017
• Subjects: Adolescent; Adult; CD3 antigen; CD8 antigen; CD8+ T cell; CD8-Positive T-Lymphocytes - immunology; Cell culture; Cell Proliferation; Cysteine; Cysteine Proteases - chemistry; Cysteine Proteases - immunology; Cysteine proteinase; epitope prediction; Epitopes; Epitopes, T-Lymphocyte - chemistry; Epitopes, T-Lymphocyte - immunology; Female; Histocompatibility antigen HLA; HLA-A2 Antigen - chemistry; HLA-A2 Antigen - immunology; Humans; IFN‐γ; Immune response (cell-mediated); Immunogenicity, Vaccine; Interleukin 10; Interleukin-10 - metabolism; Leishmania; Leishmania - enzymology; Leishmania - immunology; Leishmaniasis Vaccines - immunology; Leishmaniasis, Visceral - drug therapy; Leishmaniasis, Visceral - immunology; Leishmaniasis, Visceral - parasitology; Leukocytes (mononuclear); Leukocytes, Mononuclear - immunology; Lymphocytes T; Major histocompatibility complex; Male; Models, Molecular; Parasitic diseases; Peptides; Peptides - chemical synthesis; Peptides - chemistry; Peptides - immunology; Peripheral blood mononuclear cells; Synthetic peptides; T cell receptors; Vaccines; Visceral leishmaniasis; Young Adult; γ-Interferon; epitope prediction; IFN-γ; CD8+ T cell; visceral leishmaniasis; Leishmania

Summary Although the precise host‐defence mechanisms are not completely understood, T‐cell‐mediated immune responses are believed to play a pivotal role in controlling parasite infection. In this study, the potential HLA*A2 restricted peptides were predicted and the ability of peptides to bind HLA‐A...