A key cytosolic iron–sulfur cluster synthesis protein localizes to the mitochondrion of Toxoplasma gondii

• Published in: Molecular microbiology Vol. 115; no. 5; pp. 968 - 985
• Main Authors: Aw, Yi Tong Vincent, Seidi, Azadeh, Hayward, Jenni A., Lee, Jiwon, Makota, F. Victor, Rug, Melanie, Dooren, Giel G.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2021
• Subjects: Apicomplexa; Biosynthesis; Chemical synthesis; Clusters; Electron transfer; Eukaryotes; Homology; Iron; iron–sulfur cluster; Localization; Malaria; Membranes; Mitochondria; Parasites; Prostheses; Prosthetic groups; Protein biosynthesis; Proteins; Sulfur; Toxoplasma; Toxoplasma gondii; Toxoplasmosis; Vector-borne diseases; Toxoplasma; Apicomplexa; iron-sulfur cluster; mitochondria

Iron–sulfur (Fe‐S) clusters are prosthetic groups on proteins that function in a range of enzymatic and electron transfer reactions. Fe‐S cluster synthesis is essential for the survival of all eukaryotes. Independent Fe‐S cluster biosynthesis pathways occur in the mitochondrion, plastid, and cytosol...