Severe and protracted cholestasis in 44 young men taking bodybuilding supplements: assessment of genetic, clinical and chemical risk factors

• Published in: Alimentary pharmacology & therapeutics Vol. 49; no. 9; pp. 1195 - 1204
• Main Authors: Stolz, Andrew, Navarro, Victor, Hayashi, Paul H., Fontana, Robert J., Barnhart, Huiman X., Gu, Jiezhun, Chalasani, Naga P., Vega, Maricruz M., Bonkovsky, Herbert L., Seeff, Leonard B., Serrano, Jose, Avula, Bharathi, Khan, Ikhlas A., Cirulli, Elizabeth T., Kleiner, David E., Hoofnagle, Jay H.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2019
• Subjects: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 11 - genetics; Bile; Bile ducts; Biopsy; Bodybuilding; Chemical and Drug Induced Liver Injury - epidemiology; Chemical and Drug Induced Liver Injury - genetics; Chemical and Drug Induced Liver Injury - pathology; Cholestasis; Cholestasis - chemically induced; Cholestasis - epidemiology; Cholestasis - genetics; Cholestasis - therapy; Dietary Supplements - adverse effects; Dietary Supplements - analysis; Fibrosis; Gallbladder diseases; Genetic diversity; Genetic Predisposition to Disease - epidemiology; Hepatitis; Humans; Jaundice; Latency; Liver; Liver transplantation; Liver Transplantation - statistics & numerical data; Male; Middle Aged; Muscles - drug effects; Muscles - pathology; Performance-Enhancing Substances - adverse effects; Performance-Enhancing Substances - analysis; Performance-Enhancing Substances - chemistry; Pruritus; Risk Factors; Severity of Illness Index; Somatotypes - physiology; Steroid hormones; Young Adult

Summary Background Bodybuilding supplements can cause a profound cholestatic syndrome. Aim To describe the drug‐Induced liver injury network's experience with liver injury due to bodybuilding supplements. Methods Liver injury pattern, severity and outcomes, potential genetic associations, and e...